化学
催化作用
甲醇
丙烯酸甲酯
丙烯腈
环加成
艾地明
丙烯酸乙酯
药物化学
配体(生物化学)
产量(工程)
对映选择合成
手性配体
丙烯酸酯
立体化学
有机化学
聚合物
单体
共聚物
冶金
材料科学
受体
生物化学
作者
Nurzhan Beksultanova,Zeynep Gözükara,Mihrimah Araz,Merve Bulut,Sıdıka Polat-Çakır,Muhıttın Aygün,Özdemir Doğan
出处
期刊:Chirality
[Wiley]
日期:2021-05-26
卷期号:33 (8): 465-478
被引量:6
摘要
Abstract New derivatives of FAM (ferrocenyl aziridinyl methanol) ligands NFAM1–4 (naphthyl ferrocenyl aziridinyl methanol) and CFAM1–4 (cyclohexyl ferrocenyl aziridinyl methanol) were synthesized to form a small ligand library and used as chiral catalysts with AgOAc for the asymmetric synthesis of heteroaryl‐substituted pyrrolidines by the 1,3‐dipolar cycloaddition (1,3‐DC) reaction of azomethine ylides. 2‐Thienyl, 2‐furyl, 2‐, 3‐, and 4‐pyridyl aldimines were prepared and used with N ‐methylmaleimide, dimethyl maleate, tert ‐butyl acrylate, methyl acrylate, and acrylonitrile to form the corresponding heteroaryl‐substituted pyrrolidines. 1,3‐DC reactions yielded the expected cycloadducts in up to 89% yield and up to 76% ee that could be increased up to 95% ee upon crystallization. New chiral ligands NFAM1–4 and CFAM1–4 were fully characterized, and their absolute stereochemistry was determined by single‐crystal X‐ray analysis.
科研通智能强力驱动
Strongly Powered by AbleSci AI