老化
皮肤老化
色素沉着
抗坏血酸
人体皮肤
抗氧化剂
表皮(动物学)
化学
氧化应激
黑色素
皱纹
维生素C
生物化学
食品科学
皮肤病科
生物
医学
内科学
解剖
遗传学
作者
Nicola Zerbinati,Sabrina Sommatis,Cristina Maccario,Serena Di Francesco,Maria Chiara Capillo,Raffaele Rauso,Martha Elena Mora‐Herrera,Pier Luca Bencini,Stefania Guida,Roberto Mocchi
出处
期刊:Life
[MDPI AG]
日期:2021-04-29
卷期号:11 (5): 406-406
被引量:21
摘要
Skin ageing has many manifestations such as wrinkles, dryness, hyperpigmentation, and uneven skin tone. Extrinsic and intrinsic factors, especially solar ultraviolet light (UVB), contribute to skin ageing; its main features are brown spots, alterations in melanin pigmentation, and a decrease in collagen and hyaluronic acid linked to oxidative stress. Several studies showed that topical products containing ingredients with antioxidant activity can reduce oxidative damage; to provide a maximum anti-ageing effect to the skin, topical products can combine various ingredients. C-SHOT SERUM contains a combination of two molecules with a proven anti-ageing activity: a high percentage (30%) of a more stable vitamin C derivative, 3-O-ethyl-l-ascorbic acid, and lactic acid (1%). The product showed a high biocompatibility, assessed through an MTT assay on keratinocytes and on Reconstructed Human Epidermis (RHE, SkinEthic); the anti-ageing activity was demonstrated on human dermal fibroblasts and keratinocytes by a statistically significant increase in collagen production and a reduction of a UVB-induced DNA damage marker (γ-H2AX histone), indicating DNA protection. Moreover, a depigmenting activity, shown by a highly significant decrease in melanin content on treated Reconstructed Human Pigmented Epidermis (RHPE), was assessed. According to the data of our study, the tested product contrasts the effect of skin ageing and irregular pigmentation due to the physiological decline of the skin.
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