Aeromonas: the multifaceted middleman in the One Health world

• Aeromonas is an ubiquitous hydrotelluric bacterium. • Aeromonas is at the interface between humans, animals and the environment. • Aeromonas can be responsible for human infections following leech therapy. • Aeromonas has a high level of genome plasticity and capability of acquiring genes. • Aeromonas contributes to antimicrobial resistance gene dissemination. Aeromonas is at the interface of all the One Health components and represents an amazingly sound test case in the One Health approach, from economic loss in aquaculture tochallenges related to antibiotic-resistant bacteria selected from the environment. In human health, infections following leech therapy is an outstanding example of such One Health challenges. Aeromonads are not only ubiquitous environmental bacteria, able to rapidly colonize and cause opportunistic infections in humans and animals, they are also capable of promoting interactions and gene exchanges between the One Health components. This makes this genus a key amplifier of genetic transfer, especially of antibiotic resistance genes.