Engineering the Immune Adaptor Protein STING as a Functional Carrier (Adv. Therap. 8/2021)

Through genetic fusion with a transduction domain, the recombinant stimulator interferon genes (STING) can encapsulate cyclic dinucleotides (CDNs) and spontaneously penetrate tumor cells. This STING-based protein delivery platform represents a substantial departure from the status quo because it can serve as a functional vehicle to restore the STING signaling in immunosuppressive tumors with impaired STING expression. This is reported by Jiahe Li and co-workers in article number 2100066.