化学
炎症
肠道菌群
促炎细胞因子
脂多糖
车站3
药理学
RAR相关孤儿受体γ
白细胞介素
炎症性肠病
细胞因子
Treg细胞
作者
Juan Huang,Yang Ziyan,Yanyun Li,Xingxing Chai,Yanfang Liang,Bihua Lin,Ziyu Ye,Shaobing Zhang,Zhengping Che,Hailiang Zhang,Xueying Zhang,Zhao Zhang,Tao Chen,Weiqing Yang,Jincheng Zeng
标识
DOI:10.1186/s12967-021-02943-x
摘要
Inflammatory bowel diseases (IBD), mainly comprising ulcerative colitis (UC) and Crohn's Disease, are most often a polygenic disorder with contributions from the intestinal microbiome, defects in barrier function, and dysregulated host responses to microbial stimulation. Strategies that target the microbiota have emerged as potential therapies and, of these, probiotics have gained the greatest attention. Herein, we isolated a strain of Lactobacillus paracasei R3 (L.p R3) with strong biofilm formation ability from infant feces. Interestingly, we also found L.p R3 strain can ameliorate the general symptoms of murine colitis, alleviate inflammatory cell infiltration and inhibit Th17 while promote Treg function in murine dextran sulfate sodium (DSS)-induced colitis. Overall, this study suggested that L.p R3 strain significantly improves the symptoms and the pathological damage of mice with colitis and influences the immune function by regulating Th17/Treg cell balance in DSS-induced colitis in mice.
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