Palladium‐Catalyzed Asymmetric Hydrogenation of N‐Hydroxy‐α‐imino Phosphonates Using Brønsted Acid as Activator: The First Catalytic Enantioselective Approach to Chiral N‐Hydroxy‐α‐amino Phosphonates

Abstract The enantioselective synthesis of ring‐substituted [ N ‐(hydroxy)amino](phenyl)methylphosphonic esters via asymmetric hydrogenation of the corresponding N ‐hydroxy‐ α ‐imino phosphonates with up to 90% ee was developed using catalytic amounts of palladium(II) acetate and ( R )‐BINAP in 2,2,2‐trifluoroethanol with a Brønsted acid as an activator.