区域选择性
化学
催化作用
亲核细胞
乙醇胺
二醇
加合物
有机化学
四配位
高分子化学
组合化学
计算机图形学(图像)
计算机科学
平面的
作者
Elena Dimitrijević,Mark S. Taylor
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2013-01-01
卷期号:4 (8): 3298-3298
被引量:74
摘要
Heteraborinine-derived borinic acids serve as efficient catalysts for regioselective monofunctionalization of di- and polyols. Arylborinic acids of this type, wherein the B–OH group is incorporated into a 6π electron system, display both improved catalytic activity for functionalization of diols and enhanced stability towards air oxidation relative to the ‘parent’ diphenylborinic acid (Ph2BOH). These properties enable their applications at loadings as low as 0.1 mol% and without the need for a stabilizing precatalyst ligand (e.g., ethanolamine). Complexation studies, computation and kinetic data suggest that while the heteraborinine-derived borinic acids show significantly lower association constants with substrates than Ph2BOH, this effect is more than compensated for by the increased nucleophilicity of their tetracoordinate diol adducts.
科研通智能强力驱动
Strongly Powered by AbleSci AI