Structural and Functional Properties of the TRK Family of Neurotrophin Receptors

trk受体 神经营养素 受体 神经科学 医学 生物 内科学
作者
Mariano Barbacid
出处
期刊:Annals of the New York Academy of Sciences [Wiley]
卷期号:766 (1): 442-458 被引量:268
标识
DOI:10.1111/j.1749-6632.1995.tb26693.x
摘要

Annals of the New York Academy of SciencesVolume 766, Issue 1 p. 442-458 Structural and Functional Properties of the TRK Family of Neurotrophin Receptors MARIANO BARBACID, MARIANO BARBACID Department of Molecular Biology Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton, New Jersey 08543–4000Search for more papers by this author MARIANO BARBACID, MARIANO BARBACID Department of Molecular Biology Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton, New Jersey 08543–4000Search for more papers by this author First published: September 1995 https://doi.org/10.1111/j.1749-6632.1995.tb26693.xCitations: 202AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Levi-Montalcini, R. 1987. The nerve growth factor 35 years later. Science 237: 1154– 1162. 2 Lindsay, R. M., S. J. Wiegand, A. Altar & P. S. Distefano. 1994. Neurotrophic factors: from molecule to man. Trends Genet. 17: 182– 192. 3 Gotz, R., R. Koster, C. Winkler, F. Raulf, F. Lotspeich, M. Schartl & H. Thoenen. 1994. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372: 266– 269. 4 Chao, M. V. 1992. Neurotrophin receptors: A window into neuronal differentiation. Neuron 9: 583– 593. 5 Meakin, S. O. & E. M. Shooter. 1992. The nerve growth factor family of receptors. Trends Neurosci. 15: 323– 331. 6 Barbacid, M. 1993. Nerve growth factor: a tale of two receptors. Oncogene 8: 2033– 2042. 7 Davies, A. M., K. F. Lee & R. Jaenisch. 1993. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11: 565– 574. 8 Lee, K. F., E. Li, L. J. Huber, S. C. Landis, A. H. Sharpe, M. V. Chao & R. Jaenisch. 1992. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous systems. Cell 69: 737– 749. 9 Lee, K. F., K. Bachman, S. Landis & R. Jaenisch. 1994. Dependence on p75 for innervation of some sympathetic targets. Science 263: 1447– 1449. 10 Martin-Zanca, D., S. H. Hughes & M. Barbacid. 1986. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319: 743– 748. 11 Martin-Zanca, D., R. Oskam, G. Mitra, T. Copeland & M. Barbacid. 1989. Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell. Biol. 9: 24– 33. 12 Kaplan, D. R., D. Martin-Zanca & L. F. Parada. 1991. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350: 158– 160. 13 Klein, R., S. Q. Jing, V. Nanduri, E. O'Rourki & M. Barbacid. 1991. The trk proto oncogene encodes a receptor for nerve growth factor. Cell 65: 189– 97. 14 Klein, R., L. F. Parada, F. Coulier & M. Barbacid. 1989. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 8: 3701– 3709. 15 Klein, R., D. Conway, L. F. Parada & M. Barbacid. 1990. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61: 647– 656. 16 Middlemas, D. S., R. A. Lindberg & T. Hunter. 1991. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell. Biol. 11: 143– 153. 17 Klein, R., V. Nanduri, S. Q. Jing, F. Lamballe, P. Tapley, S. Bryant, C. Cordon-Cardo, K. R. Jones, L. F. Reichardt & M. Barbacid. 1991. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66: 395– 403. 18 Soppet, D., E. Escandon, J. Maragos, D. S. Middlemas, S. W. Reid, J. Blair, L. E. Burton, B. R. Stanton, D. R. Kaplan, T. Hunter, K. Nikolics & L. F. Parada. 1991. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65: 895– 903. 19 Squinto, S. P., T. N. Stitt, T. H. Aldrich, S. Davis, S. M. Bianco, C. Radziejewski, D. J. Glass, P. Masiakowski, M. E. Furth, D. M. Valenzuela, P. S. Distefano & G. D. Yancopoulos. 1991. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65: 885– 893. 20 Berkemeier, L. R., J. W. Winslow, D. R. Kaplan, K. Nikolics, D. V. Goeddel & A. Rosenthal. 1991. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7: 857– 866. 21 Klein, R., F. Lamballe, S. Bryant & M. Barbacid. 1992. The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8: 947– 956. 22 Ip, N. Y., C. F. Ibanez, S. H. Nye, J. McClain, P. F. Jones, D. R. Gies, L. Belluscio, M. M. Le Beau, R. Espinosa, S. P. Squinto, H. Persson & G. Yancopoulos. 1992. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA 89: 3060– 3064. 23 Lamballe, F., R. Klein & M. Barbacid. 1991. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967– 979. 24 Klein, R., R. J. Smeyne, W. Wurst, L. K. Long, B. A. Auerbach, A. L. Joyner & M. Barbacid. 1993. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75: 113– 122. 25 Smeyne, R. J., R. Klein, A. Schnapp, L. K. Long, S. Bryant, A. Lewin, S. A. Lira & M. Barbacid. 1994. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246– 249. 26 Klein, R., I. Silos-Santiago, R. J. Smeyne, S. Lira, R. Brambrilla, S. Bryant, L. Zhang, W. D. Snider & M. Barbacid. 1994. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 368: 249– 251. 27 Barbacid, M. 1994. ( Y. A. Barde, Ed.) The Trk family of neurotrophin receptors. Special issue on "Neurotrophic Factors. Neurobiol. 25: 1386– 1403. 28 Snider, W. D. 1994. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 77: 627– 638. 29 Hardie, D. G. & S. Hanks. 1994. In Protein Kinase Factsbook. Academic Press. London . 30 Meakin, S. O., U. Suter, C. C. Drinkwater, A. A. Welcher & E. M. Shooter. 1992. The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc. Natl. Acad. Sci. USA 89: 2374– 2378. 31 Barker, P. A., C. Lomen-Hoerth, E. M. Gensch, S. O. Meakin, D. J. Glass & E. M. Shooter. 1993. Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J. Biol. Chem. 268: 15150– 15157. 32 Horigome, K., J. C. Pryor, E. D. Bullock & E. M. Johnson, Jr. 1993. Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation. J. Biol. Chem. 268: 14881– 14887. 33 Schneider, R. & M. Schweiger. 1991. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Oncogene 6: 1807– 1811. 34 Pulido, D., S. Campuzano, T. Koda, J. Modolell & M. Barbacid. 1992. Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. EMBO J. 11: 391– 404. 35 Coulier, F., R. Kumar, M. Ernst, R. Klein, D. Martin-Zanca & M. Barbacid. 1990. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Mol. Cell. Biol. 10: 4202– 4210. 36 Lamballe, F., P. Tapley & M. Barbacid. 1993. trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J. 12: 3083– 3094. 37 Tsoulfas, P., D. Soppet, E. Escandon, L. Tessarollo, J. L. Mendoza-Ramirez, A. Rosenthal, K. Nikolics & L. F. Parada. 1993. The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron 10: 975– 990. 38 Valenzuela, D. M., P. C. Maisonpierre, D. J. Glass, E. Rojas, L. Nunez, Y. Kong, D. R. Gies, T. N. Stitt, N. Y. Ip & G. D. Yancopoulos. 1993. Alternative forms of rat TrkC with different functional capabilities. Neuron 10: 963– 974. 39 Cordon-Cardo, C., P. Tapley, S. Q. Jing, V. Nanduri, E. O'Rourke, F. Lamballe, K. Kovary, R. Klein, K. R. Jones, L. F. Reichardt & M. Barbacid. 1991. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66: 173– 183. 40 Ip, N. Y., T. N. Stitt, P. Tapley, R. Klein, D. J. Glass, J. Fandl, L. A. Greene, M. Barbacid & G. D. Yancopoulos. 1993. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10: 137– 149. 41 Jing, S., P. Tapley & M. Barbacid. 1992. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9: 1067– 1079. 42 Schlessinger, J. & A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron 9: 383– 391. 43 Egan, S. E. & R. A. Weinberg. 1993. The pathway to signal achievement. Nature 365: 781– 783. 44 Ohmichi, M., S. J. Decker, L. Pang & A. R. Saltiel. 1991. Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C γ 1. Biochem. Biophys. Res. Commun. 179: 217– 223. 45 Vetter, M. L., D. Martin-Zanca, L. F. Parada, J. M. Bishop & D. R. Kaplan. 1991. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-γ 1 by a kinase activity associated with the product of the trk protooncogene. Proc. Natl. Acad. Sci. USA 88: 5650– 5654. 46 Widmer, H. R., D. R. Kaplan, S. J. Rabin, K. D. Beck, F. Hefti & B. Knusel. 1993. Rapid phosphorylation of phospholipase C γ 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. J. Neurochem. 60: 2111– 2123. 47 Rhee, S. G. & K. D. Choi. 1992. Multiple forms of phospholipase C isozymes and their activation mechanisms. Adv. Second Messenger Phosphoprotein Res. 26: 35– 61. 48 Obermeier, A., R. Lammers, K. H. Wiesmuller, G. Jung, J. Schlessinger & A. Ullrich. 1993. Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex. J. Biol. Chem. 268: 22963– 22966. 49 Loeb, D. M., H. Tsao, M. H. Cobb & L. A. Greene. 1992. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk. Neuron 9: 1053– 1065. 50 Soltoff, S. P., S. L. Rabin, L. C. Cantley & D. R. Kaplan. 1992. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J. Biol. Chem. 267: 17472– 17477. 51 Ohmichi, M., S. J. Decker & A. R. Saltiel. 1992. Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. Neuron 9: 769– 777. 52 Suen, K. L., X. R. Bustelo, T. Pawson & M. Barbacid. 1993. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol. Cell. Biol. 13: 5500– 5512. 53 Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson & P. G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93– 104. 54 Qiu, M. S. & S. H. Green. 1991. NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron 7: 937– 946. 55 Muroya, K., S. Hattori & S. Nakamura. 1992. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells. Oncogene 7: 277– 281. 56 Thomas, S. M., M. Demarco, G. D'Arcangelo, S. Halegoua & J. S. Brugge. 1992. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68: 1031– 1040. 57 Schanen-King, C., A. Nel, L. K. Williams & G. Landreth. 1991. Nerve growth factor stimulates the tyrosine phosphorylation of MAP kinase in PC12 cells. Neuron 6: 915– 922. 58 Bar-Sagi, D. & J. R. Feramisco. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42: 841– 848. 59 Noda, M., M. Ko, A. Ogura, D. G. Liu, T. Amano, T. Takano & Y. Ikawa. 1985. Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature 318: 73– 75. 60 Wood, K. W., H. Qi, G. D'Arcangelo, R. C. Armstrong, T. M. Roberts & S. Halegoua. 1993. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc. Natl. Acad. Sci. USA 90: 5016– 5020. 61 Rabin, S. J., V. Cleghon & D. R. Kaplan. 1993. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol. Cell. Biol. 13: 2203– 2213. 62 Traverse, S., K. Seedorf, H. Paterson, C. J. Marshall, P. Cohen & A. Ullrich. 1994. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4: 694– 701. 63 Dikic, I., J. Schlessinger & I. Lax. 1994. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol. 4: 702– 708. 64 Glass, D. J., S. H. Nye, P. Hantzopoulos, M. J. Macchi, S. P. Squinto, M. Goldfarb & G. D. Yancopoulos. 1991. TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell 66: 405– 413. 65 Beck, K. D., F. Lamballe, R. Klein, M. Barbacid, P. E. Schauwecker, T. H. Mcneill, C. E. Finch, F. Hefti & J. R. Day. 1993. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J. Neurosci. 13: 4001– 4014. 66 Mu, X., I. Silos-Santiago, S. L. Carroll & W. D. Snider. 1993. Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia. J. Neurosci. 13: 4029– 4041. 67 Holtzman, D. M., Y. Li, L. F. Parada, S. Kinsman, C. K. Chen, J. S. Valletta, J. Zhou, J. B. Long & W. C. Mobley. 1992. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9: 465– 478. Citing Literature Volume766, Issue1Receptor Activation by Antigens, Cytokines, Hormones, and Growth FactorsSeptember 1995Pages 442-458 ReferencesRelatedInformation

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