亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Structural and Functional Properties of the TRK Family of Neurotrophin Receptors

trk受体 神经营养素 受体 神经科学 医学 生物 内科学
作者
Mariano Barbacid
出处
期刊:Annals of the New York Academy of Sciences [Wiley]
卷期号:766 (1): 442-458 被引量:267
标识
DOI:10.1111/j.1749-6632.1995.tb26693.x
摘要

Annals of the New York Academy of SciencesVolume 766, Issue 1 p. 442-458 Structural and Functional Properties of the TRK Family of Neurotrophin Receptors MARIANO BARBACID, MARIANO BARBACID Department of Molecular Biology Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton, New Jersey 08543–4000Search for more papers by this author MARIANO BARBACID, MARIANO BARBACID Department of Molecular Biology Bristol-Myers Squibb Pharmaceutical Research Institute P.O. Box 4000 Princeton, New Jersey 08543–4000Search for more papers by this author First published: September 1995 https://doi.org/10.1111/j.1749-6632.1995.tb26693.xCitations: 202AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Levi-Montalcini, R. 1987. The nerve growth factor 35 years later. Science 237: 1154– 1162. 2 Lindsay, R. M., S. J. Wiegand, A. Altar & P. S. Distefano. 1994. Neurotrophic factors: from molecule to man. Trends Genet. 17: 182– 192. 3 Gotz, R., R. Koster, C. Winkler, F. Raulf, F. Lotspeich, M. Schartl & H. Thoenen. 1994. Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372: 266– 269. 4 Chao, M. V. 1992. Neurotrophin receptors: A window into neuronal differentiation. Neuron 9: 583– 593. 5 Meakin, S. O. & E. M. Shooter. 1992. The nerve growth factor family of receptors. Trends Neurosci. 15: 323– 331. 6 Barbacid, M. 1993. Nerve growth factor: a tale of two receptors. Oncogene 8: 2033– 2042. 7 Davies, A. M., K. F. Lee & R. Jaenisch. 1993. p75-deficient trigeminal sensory neurons have an altered response to NGF but not to other neurotrophins. Neuron 11: 565– 574. 8 Lee, K. F., E. Li, L. J. Huber, S. C. Landis, A. H. Sharpe, M. V. Chao & R. Jaenisch. 1992. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous systems. Cell 69: 737– 749. 9 Lee, K. F., K. Bachman, S. Landis & R. Jaenisch. 1994. Dependence on p75 for innervation of some sympathetic targets. Science 263: 1447– 1449. 10 Martin-Zanca, D., S. H. Hughes & M. Barbacid. 1986. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319: 743– 748. 11 Martin-Zanca, D., R. Oskam, G. Mitra, T. Copeland & M. Barbacid. 1989. Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell. Biol. 9: 24– 33. 12 Kaplan, D. R., D. Martin-Zanca & L. F. Parada. 1991. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350: 158– 160. 13 Klein, R., S. Q. Jing, V. Nanduri, E. O'Rourki & M. Barbacid. 1991. The trk proto oncogene encodes a receptor for nerve growth factor. Cell 65: 189– 97. 14 Klein, R., L. F. Parada, F. Coulier & M. Barbacid. 1989. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 8: 3701– 3709. 15 Klein, R., D. Conway, L. F. Parada & M. Barbacid. 1990. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61: 647– 656. 16 Middlemas, D. S., R. A. Lindberg & T. Hunter. 1991. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol. Cell. Biol. 11: 143– 153. 17 Klein, R., V. Nanduri, S. Q. Jing, F. Lamballe, P. Tapley, S. Bryant, C. Cordon-Cardo, K. R. Jones, L. F. Reichardt & M. Barbacid. 1991. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66: 395– 403. 18 Soppet, D., E. Escandon, J. Maragos, D. S. Middlemas, S. W. Reid, J. Blair, L. E. Burton, B. R. Stanton, D. R. Kaplan, T. Hunter, K. Nikolics & L. F. Parada. 1991. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell 65: 895– 903. 19 Squinto, S. P., T. N. Stitt, T. H. Aldrich, S. Davis, S. M. Bianco, C. Radziejewski, D. J. Glass, P. Masiakowski, M. E. Furth, D. M. Valenzuela, P. S. Distefano & G. D. Yancopoulos. 1991. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell 65: 885– 893. 20 Berkemeier, L. R., J. W. Winslow, D. R. Kaplan, K. Nikolics, D. V. Goeddel & A. Rosenthal. 1991. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7: 857– 866. 21 Klein, R., F. Lamballe, S. Bryant & M. Barbacid. 1992. The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron 8: 947– 956. 22 Ip, N. Y., C. F. Ibanez, S. H. Nye, J. McClain, P. F. Jones, D. R. Gies, L. Belluscio, M. M. Le Beau, R. Espinosa, S. P. Squinto, H. Persson & G. Yancopoulos. 1992. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA 89: 3060– 3064. 23 Lamballe, F., R. Klein & M. Barbacid. 1991. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66: 967– 979. 24 Klein, R., R. J. Smeyne, W. Wurst, L. K. Long, B. A. Auerbach, A. L. Joyner & M. Barbacid. 1993. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75: 113– 122. 25 Smeyne, R. J., R. Klein, A. Schnapp, L. K. Long, S. Bryant, A. Lewin, S. A. Lira & M. Barbacid. 1994. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246– 249. 26 Klein, R., I. Silos-Santiago, R. J. Smeyne, S. Lira, R. Brambrilla, S. Bryant, L. Zhang, W. D. Snider & M. Barbacid. 1994. Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 368: 249– 251. 27 Barbacid, M. 1994. ( Y. A. Barde, Ed.) The Trk family of neurotrophin receptors. Special issue on "Neurotrophic Factors. Neurobiol. 25: 1386– 1403. 28 Snider, W. D. 1994. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. Cell 77: 627– 638. 29 Hardie, D. G. & S. Hanks. 1994. In Protein Kinase Factsbook. Academic Press. London . 30 Meakin, S. O., U. Suter, C. C. Drinkwater, A. A. Welcher & E. M. Shooter. 1992. The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor. Proc. Natl. Acad. Sci. USA 89: 2374– 2378. 31 Barker, P. A., C. Lomen-Hoerth, E. M. Gensch, S. O. Meakin, D. J. Glass & E. M. Shooter. 1993. Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J. Biol. Chem. 268: 15150– 15157. 32 Horigome, K., J. C. Pryor, E. D. Bullock & E. M. Johnson, Jr. 1993. Mediator release from mast cells by nerve growth factor. Neurotrophin specificity and receptor mediation. J. Biol. Chem. 268: 14881– 14887. 33 Schneider, R. & M. Schweiger. 1991. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Oncogene 6: 1807– 1811. 34 Pulido, D., S. Campuzano, T. Koda, J. Modolell & M. Barbacid. 1992. Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. EMBO J. 11: 391– 404. 35 Coulier, F., R. Kumar, M. Ernst, R. Klein, D. Martin-Zanca & M. Barbacid. 1990. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Mol. Cell. Biol. 10: 4202– 4210. 36 Lamballe, F., P. Tapley & M. Barbacid. 1993. trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J. 12: 3083– 3094. 37 Tsoulfas, P., D. Soppet, E. Escandon, L. Tessarollo, J. L. Mendoza-Ramirez, A. Rosenthal, K. Nikolics & L. F. Parada. 1993. The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron 10: 975– 990. 38 Valenzuela, D. M., P. C. Maisonpierre, D. J. Glass, E. Rojas, L. Nunez, Y. Kong, D. R. Gies, T. N. Stitt, N. Y. Ip & G. D. Yancopoulos. 1993. Alternative forms of rat TrkC with different functional capabilities. Neuron 10: 963– 974. 39 Cordon-Cardo, C., P. Tapley, S. Q. Jing, V. Nanduri, E. O'Rourke, F. Lamballe, K. Kovary, R. Klein, K. R. Jones, L. F. Reichardt & M. Barbacid. 1991. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66: 173– 183. 40 Ip, N. Y., T. N. Stitt, P. Tapley, R. Klein, D. J. Glass, J. Fandl, L. A. Greene, M. Barbacid & G. D. Yancopoulos. 1993. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron 10: 137– 149. 41 Jing, S., P. Tapley & M. Barbacid. 1992. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9: 1067– 1079. 42 Schlessinger, J. & A. Ullrich. 1992. Growth factor signaling by receptor tyrosine kinases. Neuron 9: 383– 391. 43 Egan, S. E. & R. A. Weinberg. 1993. The pathway to signal achievement. Nature 365: 781– 783. 44 Ohmichi, M., S. J. Decker, L. Pang & A. R. Saltiel. 1991. Nerve growth factor binds to the 140 kd trk proto-oncogene product and stimulates its association with the src homology domain of phospholipase C γ 1. Biochem. Biophys. Res. Commun. 179: 217– 223. 45 Vetter, M. L., D. Martin-Zanca, L. F. Parada, J. M. Bishop & D. R. Kaplan. 1991. Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-γ 1 by a kinase activity associated with the product of the trk protooncogene. Proc. Natl. Acad. Sci. USA 88: 5650– 5654. 46 Widmer, H. R., D. R. Kaplan, S. J. Rabin, K. D. Beck, F. Hefti & B. Knusel. 1993. Rapid phosphorylation of phospholipase C γ 1 by brain-derived neurotrophic factor and neurotrophin-3 in cultures of embryonic rat cortical neurons. J. Neurochem. 60: 2111– 2123. 47 Rhee, S. G. & K. D. Choi. 1992. Multiple forms of phospholipase C isozymes and their activation mechanisms. Adv. Second Messenger Phosphoprotein Res. 26: 35– 61. 48 Obermeier, A., R. Lammers, K. H. Wiesmuller, G. Jung, J. Schlessinger & A. Ullrich. 1993. Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex. J. Biol. Chem. 268: 22963– 22966. 49 Loeb, D. M., H. Tsao, M. H. Cobb & L. A. Greene. 1992. NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk. Neuron 9: 1053– 1065. 50 Soltoff, S. P., S. L. Rabin, L. C. Cantley & D. R. Kaplan. 1992. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J. Biol. Chem. 267: 17472– 17477. 51 Ohmichi, M., S. J. Decker & A. R. Saltiel. 1992. Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains. Neuron 9: 769– 777. 52 Suen, K. L., X. R. Bustelo, T. Pawson & M. Barbacid. 1993. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Mol. Cell. Biol. 13: 5500– 5512. 53 Pelicci, G., L. Lanfrancone, F. Grignani, J. McGlade, F. Cavallo, G. Forni, I. Nicoletti, F. Grignani, T. Pawson & P. G. Pelicci. 1992. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell 70: 93– 104. 54 Qiu, M. S. & S. H. Green. 1991. NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron 7: 937– 946. 55 Muroya, K., S. Hattori & S. Nakamura. 1992. Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells. Oncogene 7: 277– 281. 56 Thomas, S. M., M. Demarco, G. D'Arcangelo, S. Halegoua & J. S. Brugge. 1992. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell 68: 1031– 1040. 57 Schanen-King, C., A. Nel, L. K. Williams & G. Landreth. 1991. Nerve growth factor stimulates the tyrosine phosphorylation of MAP kinase in PC12 cells. Neuron 6: 915– 922. 58 Bar-Sagi, D. & J. R. Feramisco. 1985. Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell 42: 841– 848. 59 Noda, M., M. Ko, A. Ogura, D. G. Liu, T. Amano, T. Takano & Y. Ikawa. 1985. Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line. Nature 318: 73– 75. 60 Wood, K. W., H. Qi, G. D'Arcangelo, R. C. Armstrong, T. M. Roberts & S. Halegoua. 1993. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc. Natl. Acad. Sci. USA 90: 5016– 5020. 61 Rabin, S. J., V. Cleghon & D. R. Kaplan. 1993. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol. Cell. Biol. 13: 2203– 2213. 62 Traverse, S., K. Seedorf, H. Paterson, C. J. Marshall, P. Cohen & A. Ullrich. 1994. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol. 4: 694– 701. 63 Dikic, I., J. Schlessinger & I. Lax. 1994. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol. 4: 702– 708. 64 Glass, D. J., S. H. Nye, P. Hantzopoulos, M. J. Macchi, S. P. Squinto, M. Goldfarb & G. D. Yancopoulos. 1991. TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor. Cell 66: 405– 413. 65 Beck, K. D., F. Lamballe, R. Klein, M. Barbacid, P. E. Schauwecker, T. H. Mcneill, C. E. Finch, F. Hefti & J. R. Day. 1993. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J. Neurosci. 13: 4001– 4014. 66 Mu, X., I. Silos-Santiago, S. L. Carroll & W. D. Snider. 1993. Neurotrophin receptor genes are expressed in distinct patterns in developing dorsal root ganglia. J. Neurosci. 13: 4029– 4041. 67 Holtzman, D. M., Y. Li, L. F. Parada, S. Kinsman, C. K. Chen, J. S. Valletta, J. Zhou, J. B. Long & W. C. Mobley. 1992. p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9: 465– 478. Citing Literature Volume766, Issue1Receptor Activation by Antigens, Cytokines, Hormones, and Growth FactorsSeptember 1995Pages 442-458 ReferencesRelatedInformation
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
15秒前
20秒前
畅快行云发布了新的文献求助50
29秒前
千里草发布了新的文献求助10
1分钟前
天天快乐应助gy采纳,获得10
1分钟前
畅快行云完成签到,获得积分10
1分钟前
Wilson完成签到 ,获得积分10
2分钟前
义气的书雁完成签到,获得积分10
2分钟前
4分钟前
孤独靖柏发布了新的文献求助10
4分钟前
丘比特应助孤独靖柏采纳,获得10
5分钟前
鬼见愁应助Wei采纳,获得10
5分钟前
5分钟前
5分钟前
傅夜山发布了新的文献求助30
5分钟前
wangsiheng发布了新的文献求助10
5分钟前
wangsiheng完成签到,获得积分20
6分钟前
dormraider完成签到,获得积分10
6分钟前
充电宝应助yang采纳,获得10
7分钟前
丘比特应助傅夜山采纳,获得10
7分钟前
狂奔的蜗牛完成签到,获得积分10
8分钟前
8分钟前
卓头OvQ发布了新的文献求助10
8分钟前
卓头OvQ完成签到,获得积分10
8分钟前
李健应助科研通管家采纳,获得20
8分钟前
丘比特应助傅夜山采纳,获得30
8分钟前
9分钟前
yang发布了新的文献求助10
9分钟前
9分钟前
lixuebin完成签到 ,获得积分10
9分钟前
9分钟前
9分钟前
yang完成签到,获得积分10
9分钟前
千里草完成签到,获得积分10
10分钟前
12分钟前
虞鱼瑜发布了新的文献求助10
12分钟前
12分钟前
12分钟前
傅夜山发布了新的文献求助10
12分钟前
丫丫完成签到,获得积分10
12分钟前
高分求助中
Lire en communiste 1000
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 800
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Becoming: An Introduction to Jung's Concept of Individuation 600
肝病学名词 500
Evolution 3rd edition 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3171568
求助须知:如何正确求助?哪些是违规求助? 2822431
关于积分的说明 7939235
捐赠科研通 2483077
什么是DOI,文献DOI怎么找? 1322952
科研通“疑难数据库(出版商)”最低求助积分说明 633826
版权声明 602647