Expression and prognostic roles of beta-catenin in hepatocellular carcinoma: correlation with tumor progression and postoperative survival.

肝细胞癌 免疫组织化学 细胞周期蛋白D1 病理 肿瘤进展 连环素 六氯环己烷 连环蛋白 医学 BETA(编程语言) 癌症研究 生物 癌症 内科学 细胞周期 Wnt信号通路 信号转导 程序设计语言 生物化学 计算机科学
作者
Satoshi Inagawa,Michio Itabashi,Shinya Adachi,Toru Kawamoto,Masao Hori,Jun Shimazaki,Fuyo Yoshimi,Katashi Fukao
出处
期刊:PubMed 卷期号:8 (2): 450-6 被引量:74
链接
标识
摘要

Although hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the human liver, the molecular changes and mechanisms that regulate its development and progression remain unclear. In the present study, we investigated the correlation between beta-catenin expression and clinical outcome in 51 patients with relatively small (maximal diameter < 30 mm), solitary HCCs.The tumors were classified according to histological tumor differentiation (grade I, 11 tumors; grade II, 28 tumors; grade III, 12 tumors). Using immunohistochemical methods to detect nuclear accumulation of beta-catenin, we investigated the correlation between beta-catenin expression and clinical outcome and compared the correlation with cyclin D1, Ki-67, and E-cadherin.Focal or generalized nuclear beta-catenin expression was observed in 36.4% (4 of 11) of the grade I tumors, 39.3% (11 of 28) of the grade II tumors, and 25% (3 of 12) of the grade III tumors. Nuclear beta-catenin-positive grade III tumors were associated with significantly poorer survival (P = 0.004), whereas none of the patients with nuclear beta-catenin-negative grade I tumors died. With regard to proliferative activity, positive nuclear beta-catenin staining correlated significantly with an increased Ki-67 labeling index in grade I (P < 0.0001) and grade III (P = 0.0045) tumors and with reduced epithelial cadherin expression in the cell membrane (P < 0.001). In contrast, no association with the expression of cyclin D1, one of the target factors of beta-catenin, was detected.Our present data suggest that beta-catenin plays important roles in promoting tumor progression by stimulating tumor cell proliferation and reducing the activity of cell adhesion systems and is associated with a poor prognosis, especially in patients with poorly differentiated HCCs.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xunxunmimi发布了新的文献求助10
1秒前
2秒前
乂贰ZERO叁完成签到 ,获得积分10
2秒前
思源应助酷炫的之柔采纳,获得10
3秒前
xiaohu发布了新的文献求助10
3秒前
Ant应助小李采纳,获得30
4秒前
5秒前
5秒前
苹果初阳发布了新的文献求助10
8秒前
此间少年完成签到,获得积分10
8秒前
10秒前
Hairee发布了新的文献求助10
10秒前
思源应助baonali采纳,获得10
11秒前
WXR完成签到,获得积分10
13秒前
蓝胖胖蓝完成签到,获得积分10
14秒前
蜘蛛道理完成签到 ,获得积分10
14秒前
LZM完成签到,获得积分10
15秒前
WuLunbi发布了新的文献求助10
16秒前
17秒前
18秒前
18秒前
19秒前
我还以为春天到了完成签到 ,获得积分10
19秒前
亲爱的融完成签到,获得积分10
20秒前
SherlockHe发布了新的文献求助10
21秒前
momo发布了新的文献求助10
22秒前
米饭多加水完成签到 ,获得积分10
24秒前
潘善若发布了新的文献求助10
25秒前
Jasper应助anna采纳,获得10
29秒前
zzr元亨利贞完成签到,获得积分10
31秒前
riccixuu完成签到 ,获得积分10
32秒前
潘善若发布了新的文献求助10
33秒前
JK完成签到,获得积分20
34秒前
35秒前
35秒前
35秒前
苹果初阳完成签到,获得积分10
35秒前
SherlockHe完成签到,获得积分10
35秒前
拉长的面包完成签到,获得积分10
36秒前
量子星尘发布了新的文献求助10
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989263
求助须知:如何正确求助?哪些是违规求助? 3531418
关于积分的说明 11253814
捐赠科研通 3270066
什么是DOI,文献DOI怎么找? 1804884
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136