Eotaxin (CCL11) and Eotaxin-2 (CCL24) Induce Recruitment of Eosinophils, Basophils, Neutrophils, and Macrophages As Well As Features of Early- and Late-Phase Allergic Reactions Following Cutaneous Injection in Human Atopic and Nonatopic Volunteers

嗜酸性粒细胞趋化因子 CCL11型 免疫学 趋化因子 嗜酸性粒细胞 CCR3 皮内注射 脱颗粒 白细胞介素5 医学 卵清蛋白 细胞因子 炎症 白细胞介素 免疫系统 趋化因子受体 哮喘 内科学 受体
作者
Andrew Menzies‐Gow,Sun Ying,Ian Sabroe,Victoria L. Stubbs,Dulce Soler,Timothy J. Williams,A. B. Kay
出处
期刊:Journal of Immunology [American Association of Immunologists]
卷期号:169 (5): 2712-2718 被引量:212
标识
DOI:10.4049/jimmunol.169.5.2712
摘要

Eotaxin and eotaxin-2, acting through CCR3, are potent eosinophil chemoattractants both in vitro and in animal models. In this study we examined the capacity of eotaxin and eotaxin-2 to recruit eosinophils and other inflammatory cells in vivo in human atopic and nonatopic skin. Skin biopsies taken after intradermal injection of eotaxin and eotaxin-2 were examined by immunohistochemistry. Allergen- and diluent-challenged sites were used as positive and negative controls. Eotaxin and eotaxin-2 produced a dose- and time-dependent local eosinophilia of comparable intensity in both atopic and nonatopic individuals. This was associated with an acute wheal and flare response at the site of injection and development of a cutaneous late phase reaction in a proportion of subjects. There was an accompanying decrease in mast cell numbers. Both chemokines also induced the accumulation of basophils and an unexpected early infiltration of neutrophils. Macrophages were prominent at the 24-h point. Although there was surface CCR3 expression on neutrophils in whole blood, we were unable to demonstrate any functional neutrophil responses to eotaxin in vitro. Thus, intradermal injection of eotaxin and eotaxin-2 in humans induced infiltration of eosinophils and other inflammatory cells as well as changes consistent with CC chemokine-induced mast cell degranulation.
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