皮肤白血病
粒细胞白血病
长春新碱
强的松
医学
白血病
皮肤
病理
癌症研究
免疫学
内科学
化疗
环磷酰胺
作者
Jack Ansell,Jag Bhawan,Liberto Pechet
标识
DOI:10.1111/j.1600-0560.1980.tb01199.x
摘要
A patient with chronic myelocytic leukemia (CML) in blast transformation with extensive involvement of the skin is reported. The leukemic infiltrates consisted of blasts with lymphoblastoid morphology which were positive for terminal deoxynucleotidyl transferase (TdT) by fluorescent assay. The infiltrates rapidly resolved with vincristine and prednisone therapy. Similar recurrences 4 and 8 months later responded as dramatically to the same therapy and to cytosine arabinoside. This unusual case of extensive leukemia cutis supports the evidence that patients in blast crisis with TdT positive cells are responsive to vincristine and prednisone. The implications of this case in terms of the origin of these cells based upon morphology and TdT content, as well as the diagnosis and therapy, are discussed.
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