Leukopenia, Trimethoprim-Sulfamethoxazole, and Folinic Acid

Letters and Corrections1 January 1985Leukopenia, Trimethoprim-Sulfamethoxazole, and Folinic AcidHARRY HOLLANDER, M.D.HARRY HOLLANDER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-102-1-138_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: After several reports of the high incidence of leukopenia in patients with the acquired immunodeficiency syndrome after the use of high-dose trimethoprim-sulfamethoxazole (1, 2), Kinzie and Taylor (3) suggested that all patients should receive prophylactic folinic acid. Although the biochemical basis of this recommendation is sound, in practice this has not been efficacious. The unusual sensitivity of these patients' bone marrow to various antibiotic agents is borne out by a recent report of severe leukopenia seen during therapy with pentamidine, the other accepted treatment forPneumocystis cariniipneumonia (4). These cytopenias are commonly seen in conjunction with...References1. GORDINSIMONWOFSYMILLS FGCJ. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1984;100:495-9. LinkGoogle Scholar2. KOVACSHEIMENZMACHER JJA. Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann Intern Med. 1984;100:663-71. LinkGoogle Scholar3. KINZIETAYLOR BJ. Trimethoprim and folinic acid [Letter]. Ann Intern Med. 1984;101:565. LinkGoogle Scholar4. . Severe neutropenia during pentamidine treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome—New York City. MMWR. 1984;33:65-7. MedlineGoogle Scholar5. JAFFEAMMANNABRAMSLEWISGOLDEN HADBJ. Complications of co-trimoxazole in treatment of AIDS-associated Pneumocystis carinii pneumonia in homosexual men. Lancet. 1983;2:1109-11. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: HARRY HOLLANDER, M.D.Affiliations: University of California, San Francisco San Franciso, CA 94143 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySulfonamide Antibacterial AgentsVitamins in HIV InfectionNutrition and HIV infection in childrenVitamins and minerals in HIV infectionChemoprophylaxis with Oral Trimethoprim-sulfamethoxazole In Otitis MediaTrimethoprim-Sulfamethoxazole and Other SulfonamidesEXTRAPYRAMIDAL SYMPTOMS IN AIDS PATIENTS GIVEN LOW-DOSE METOCLOPRAMIDE OR CHLORPROMAZINE 1 January 1985Volume 102, Issue 1Page: 138-138KeywordsAIDSAntibioticsBone marrowPneumocystis carinii pneumonia ePublished: 1 December 2008 Issue Published: 1 January 1985 PDF downloadLoading ...