酮康唑
体内
乳过氧化物酶
体外
甲状腺
碘
抗甲状腺药
内分泌学
药理学
化学
内科学
药品
医学
生物
格雷夫斯病
酶
生物化学
皮肤病科
有机化学
过氧化物酶
生物技术
抗真菌
作者
Frédéric Comby,Jean F. Lagorce,Jacques Buxeraud,C Raby
标识
DOI:10.1111/j.2042-7158.1994.tb03719.x
摘要
Inspection of the chemical structure of ketoconazole indicates that it may have antithyroid activity. The antithyroid action of this drug was demonstrated in-vitro and in-vivo. In-vitro, it was found to form a complex with iodine (formation constant Kc 141 L mol-1), and to inhibit lactoperoxidase (IC50 2 x 10(-4) M). Its effects in-vivo in the rat were assessed by assay of circulating-thyroxine, and from the histological appearance of the thyroid gland. Thyroid gland weight was increased in rats treated with ketoconazole.
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