低牛磺酸
代谢组学
牛磺酸
化学
苯丙氨酸
代谢途径
季枯
药理学
气相色谱-质谱法
生物化学
色氨酸
新陈代谢
质谱法
医学
色谱法
氨基酸
百草枯
作者
Xinhua Dai,Maozhu Liu,Shuyun Xu,Han Zhao,Xuezhi Li,Yangjuan Bai,Yuangao Zou,Yunfei An,Fei Fan,Jing Zhang,Bei Cai
标识
DOI:10.1016/j.fct.2023.113765
摘要
Diquat (DQ) has been confirmed to be toxic to humans and responsible for severe health impairment. While to date, very little is known about the toxicological mechanisms of DQ. Thus, investigations to discover the toxic targets and potential biomarkers of DQ poisoning are urgently needed. In this study, a metabolic profiling analysis was conducted to reveal the changes of metabolites of plasma and find out the potential biomarkers of DQ intoxication by GC-MS. First, multivariate statistical analysis demonstrated that acute DQ poisoning can lead to metabolomic changes in human plasma. Then, metabolomics studies showed that 31 of the identified metabolites were significantly altered by DQ. Pathway analysis indicated that three primarily metabolic pathways including phenylalanine, tyrosine and tryptophan biosynthesis, taurine and hypotaurine metabolism, and phenylalanine metabolism were affected by DQ, resulting in the perturbations of phenylalanine, tyrosine, taurine, and cysteine. Finally, the results of receiver operating characteristic analysis showed the above four metabolites could be used as reliable tools for the diagnosis and severity assessments of DQ intoxication. These data provided the theoretical basis for basic research to understand the potential mechanisms of DQ poisoning, and also identified the desirable biomarkers with great potential for clinical applications.
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