癫痫持续状态
托珠单抗
医学
耐火材料(行星科学)
癫痫
儿科
年轻人
内科学
精神科
疾病
天体生物学
物理
作者
Marie‐Laure Girardin,Thomas Flamand,Ombeline Roignot,Marie‐Thérèse Abi Warde,Véronique Mutschler,Paul Voulleminot,Max Guillot,Vera Dinkelacker,Anne de Saint Martin
出处
期刊:Epilepsia
[Wiley]
日期:2023-03-24
卷期号:64 (6)
被引量:8
摘要
Abstract New onset refractory status epilepticus (NORSE) is a rare and devastating condition occurring in a previously healthy patient. It is called febrile infection‐related epilepsy syndrome (FIRES) when preceded by a febrile infection. It often leads to intensive care treatment, including antiseizure drugs in combination with anesthetic agents, and sometimes ketogenic diet. The mortality rate is high, and severe epileptic and neuropsychiatric sequelae are usually observed. Based on the possible role of neuroinflammation, intravenous immunoglobulin, corticosteroids, and immunomodulatory treatment (anti‐IL1, IL6) can be added. We describe here a child and a young adult with FIRES, both treated with tocilizumab. We observed a rapid positive response on the status epilepticus and good tolerance, but different neurological outcomes for our two patients. Further prospective studies may be necessary both to confirm the efficacy and the safety of this promising treatment and to optimize the immunomodulatory strategy in FIRES/NORSE.
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