拟南芥
雄蕊
生殖细胞
控制(管理)
生物
细胞生物学
计算机科学
植物
基因
人工智能
遗传学
花粉
突变体
作者
Chan Liu,Hui Shi,Yuting Han,Pan Wang,Kexin Li,Zhishuai Zhang,Jiazheng Liu,Yafeng Zheng,Linlin Li,Limei Lin,Liang Chen,Bo Qin,Hua Han,Shu‐Nong Bai,Xiao Liu,Wenqian Chen,Feng Zhao
标识
DOI:10.1101/2024.10.17.618875
摘要
Abstract A central question in developmental biology is how the germline is established. We have studied the specification of the male germ cells (GCs) within the anther 1–3 . Hereby, we have focused on the potential role of mechanics, an aspect of anther development which has been very poorly characterized 2,4 . Using a combination of live imaging and mechanical measurements, we provide evidence that GCs originate in a special micro-mechanical niche, where inner tissues exert ‘push’ on outer cell layers, placing them under compression. Mechanical perturbations significantly disrupted the GC specification and patterning. Moreover, we found that the master genetic regulator SPOROCYTELESS/NOZZLE (SPL/NZZ) 5,6 is central in establishing this micro-mechanical environment by softening the cell wall. The mechanical cues, in turn, stabilize the transcription of SPL/NZZ . We propose here an intrinsic growth-derived mechano-chemical feedback loop that drives germ-cell fate acquisition.
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