ACVR2B型
FGF21型
激活素2型受体
下调和上调
产热素
激活素受体
内分泌学
内科学
化学
磷酸化
解偶联蛋白
转化生长因子
细胞生物学
受体
生物
脂肪组织
成纤维细胞生长因子
转化生长因子β信号通路
褐色脂肪组织
生物化学
医学
基因
作者
Masayuki Sakaki,Yuji O. Kamatari,Akira Kurisaki,Masayuki Funaba,Osamu Hashimoto
标识
DOI:10.1016/j.mce.2024.112326
摘要
Activin E activates brown and beige adipocytes and has been controversially implicated as a factor that induces obesity and fatty liver. Here, we sought to address this controversial issue by producing recombinant human activin E to evaluate its effects on HB2 brown adipocytes in vitro. Activin E increased uncoupling protein 1 (Ucp1) and fibroblast growth factor 21 (Fgf21) mRNA expression in the adipocytes. This upregulation was suppressed by SB431542, an inhibitor of activin receptor-like kinase (Alk) TGF-β type I receptors. SB431542 also inhibited the activin E-induced phosphorylation of Smad2/3. A promoter assay using a CAGA-Luc reporter and Alk expression vectors revealed that activin E activated the TGF-β/activin pathway via Alk7. The upregulation of Ucp1 and Fgf21 mRNA might be mediated through Alk7 and Smad2/3 phosphorylation. Activin E is a potential stimulator of energy expenditure by activating brown adipocytes and highlights its potential as a therapeutic target for treating obesity.
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