Association between immunoglobulin G N-glycosylation and lupus nephritis in female patients with systemic lupus erythematosus: a case-control study

狼疮性肾炎 医学 接收机工作特性 聚糖 糖基化 免疫学 胃肠病学 系统性红斑狼疮 免疫球蛋白G 内科学 肾炎 曲线下面积 抗体 糖蛋白 化学 生物化学 疾病
作者
Xinxia Lu,Liangao Wang,Meng Wang,Yuejin Li,Qinqin Zhao,Yanjun Shi,Yujing Zhang,Yingjie Wang,Wei Wang,Long Ji,Haifeng Hou,Dong Li
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:14 被引量:5
标识
DOI:10.3389/fimmu.2023.1257906
摘要

Lupus nephritis (LN) is a crucial complication of systemic lupus erythematosus (SLE) and has important clinical implications in guiding treatment. N-glycosylation of immunoglobulin G (IgG) plays a key role in the development of SLE by affecting the balance of anti-inflammatory and proinflammatory responses. This study aimed to evaluate the performance of IgG N-glycosylation for diagnosing LN in a sample of female SLE patients.This case-control study recruited 188 women with SLE, including 94 patients with LN and 94 age-matched patients without LN. The profiles of plasma IgG N-glycans were detected by hydrophilic interaction chromatography with ultra-performance liquid chromatography (HILIC-UPLC). A multivariate logistic regression model was used to explore the associations between IgG N-glycans and LN. A diagnostic model was developed using the significant glycans as well as demographic factors. The performance of IgG N-glycans in the diagnosis of LN was evaluated by receiver operating characteristic (ROC) curve analysis, and the area under the curve (AUC) and its 95% confidence interval (CI) were calculated.There were significant differences in 9 initial glycans (GP2, GP4, GP6, GP8, GP10, GP14, GP16, GP18 and GP23) between women with SLE with and without LN (P < 0.05). The levels of sialylated, galactosylated and fucosylated glycans were significantly lower in the LN patients than in the control group, while bisected N-acetylglucosamine (GlcNAc) glycans were increased in LN patients (P < 0.05). GP8, GP10, GP18, and anemia were included in our diagnostic model, which performed well in differentiating female SLE patients with LN from those without LN (AUC = 0.792, 95% CI: 0.727 to 0.858).Our findings indicate that decreased sialylation, galactosylation, and core fucosylation and increased bisecting GlcNAc might play a role in the development of LN by upregulating the proinflammatory response of IgG. IgG N-glycans can serve as potential biomarkers to differentiate individuals with LN among SLE patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
攸宁完成签到,获得积分10
1秒前
luochen完成签到,获得积分10
1秒前
枕月听松完成签到,获得积分10
1秒前
虚幻谷秋完成签到,获得积分10
2秒前
xshzhou完成签到,获得积分10
2秒前
logolush完成签到 ,获得积分10
2秒前
skysleeper完成签到,获得积分10
2秒前
to高坚果完成签到,获得积分20
3秒前
执意完成签到 ,获得积分10
4秒前
longchen关注了科研通微信公众号
4秒前
曹沛岚完成签到,获得积分10
4秒前
jzmupyj完成签到,获得积分10
5秒前
华仔应助柠檬很酸采纳,获得10
5秒前
Min完成签到,获得积分10
6秒前
6秒前
陈富贵完成签到 ,获得积分10
7秒前
生动沅完成签到,获得积分10
7秒前
wmm完成签到,获得积分10
8秒前
在水一方应助Emon采纳,获得10
8秒前
nickel完成签到,获得积分10
9秒前
DireWolf完成签到 ,获得积分10
9秒前
霸天虎完成签到,获得积分10
10秒前
shineshine完成签到 ,获得积分10
10秒前
畅快的煜祺完成签到,获得积分10
10秒前
研友_X894JZ完成签到 ,获得积分10
10秒前
研友_Z60NmL完成签到 ,获得积分10
11秒前
Orange应助zxyyxz采纳,获得10
11秒前
13秒前
文艺的枫叶完成签到 ,获得积分10
13秒前
jzmulyl完成签到,获得积分10
14秒前
一块小白糖完成签到,获得积分10
14秒前
慧喆完成签到 ,获得积分10
14秒前
奋斗者完成签到,获得积分10
15秒前
16秒前
旧雨新知完成签到 ,获得积分0
17秒前
hi应助雪山飞龙采纳,获得10
17秒前
18秒前
浅辰完成签到 ,获得积分10
18秒前
风中的冰蓝完成签到,获得积分10
18秒前
Katyusha完成签到 ,获得积分10
18秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968593
求助须知:如何正确求助?哪些是违规求助? 3513416
关于积分的说明 11167791
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794507
邀请新用户注册赠送积分活动 875170
科研通“疑难数据库(出版商)”最低求助积分说明 804671