Enhancing Brightness and Photostability of Organic Small Molecular Fluorescent Dyes Through Inhibiting Twisted Intramolecular Charge Transfer (TICT)※

During the past 170 years, organic small molecular fluorescent dyes had been widely applied in fluorescence labeling, fluorescence probes and bioimaging.And their structures and performances continually evolved with development of synthetic method and application.However, the emerging super-resolution imaging put forward higher requirements at brightness, stability and switching performance of organic small molecular fluorescent dyes, which also offers new opportunity for developing novel dyes at the same time.So, chemists presently pay more attentions on brightness and photostability.Twisted intramolecular charge transfer (TICT), the major nonradiative decay channel in organic small molecular fluorescent dyes, seriously decrease brightness and photostability.Therefore, inhibiting TICT has became the crucial strategy to develop organic small molecular fluorescent dyes towards super-resolution imaging.This review will firstly demonstrate mechanism and development of TICT and emphatically introduce the progress in improving organic small molecular fluorescent dyes based on inhibiting TICT.