Natural compound Sanggenon C inhibits porcine reproductive and respiratory syndrome virus replication in piglets

猪繁殖与呼吸综合征病毒 生物 病毒 呼吸系统 体内 病毒复制 动脉瘤 免疫学 药理学 病毒学 内科学 医学 生物技术 传染病(医学专业) 解剖 疾病 2019年冠状病毒病(COVID-19)
作者
Xiao Liu,Mengsun Yu,Jianyu He,Xiliang Jiang,Shuangquan Zhang,Dan Wang,Yanan Zhu,Zifang Zheng,Yunpeng Fan,Yupeng Yin,Shuqi Xiao
出处
期刊:Veterinary Microbiology [Elsevier]
卷期号:290: 109991-109991
标识
DOI:10.1016/j.vetmic.2024.109991
摘要

Porcine reproductive and respiratory syndrome virus is one of the main pathogens threatening the global pig industry, and there is still a lack of effective therapeutic drugs. Sanggenon C is a flavanone Diels-Alder adduct compound extracted from the root bark of the mulberry genus, which has blood pressure-reducing, anti-atherosclerotic, anti-oxidative, and anti-inflammatory effects. In our previous study, Sanggenon C was confirmed to significantly inhibit PRRSV replication in vitro. However, its antiviral potential to inhibit PRRSV infection in vivo has not been evaluated in piglets. Here, the antiviral effect of Sanggenon C was evaluated in PRRSV-challenged piglets based on assessments of rectal temperature, viral load, pathological changes of lung tissue and secretion of inflammatory cytokines. The results showed that Sanggenon C treatment relieved the clinical symptoms, reduced the viral loads in the lungs and bloods, alleviated the pathological damage of lung tissue, decreased the secretion of inflammatory cytokines, and shorten the excretion time of virus from the oral and nasal secretions and feces of piglets after PRRSV infection. The results indicated that Sanggenon C is a promising anti-PRRSV drug, which provides a new strategy for the prevention and control of PRRS in clinical practice.
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