炎症
巨噬细胞
细胞凋亡
新加坡元1
细胞生物学
化学
蛋白激酶B
下调和上调
糖皮质激素
糖皮质激素受体
信号转导
生物
激酶
免疫学
生物化学
内分泌学
体外
基因
作者
Lei Zhu,Lian Zhou,Xifeng Wang,Qingcui Zheng,Fenfang Zhan,Lanqian Zhou,Yao Dong,Yanhong Xiong,Pengcheng Yi,Xu Guohai,Fuzhou Hua
标识
DOI：10.1016/j.bcp.2024.116050
摘要
The side effects of high-dose dexamethasone in anti-infection include increased ROS production and immune cell apoptosis. Dexamethasone effectively activates serum/glucocorticoid-regulated kinase 1 (SGK1), which upregulates various ion channels by activating store-operated calcium entry (SOCE), leading to Ca
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