便秘
PI3K/AKT/mTOR通路
山奈酚
西番莲
痔疮
化学
组分(热力学)
蛋白激酶B
发酵
激情
食品科学
药理学
信号转导
医学
心理学
内科学
槲皮素
生物化学
外科
物理
心理治疗师
热力学
抗氧化剂
作者
Xiaotian Xu,Xinhui Li,Xingshu Wei,Xiaoqun Duan,Yu-Hui Wang
标识
DOI:10.1016/j.jff.2024.106112
摘要
Passion fruit peel fermentation extract (PFPFE) increased gastrointestinal transport power and fecal moisture content, protected the structural integrity of colon tissue, and reduced inflammatory infiltration. PFPFE also increased secretion of the ET-1, GAS, MTL, and SP, and decreased secretion of the inhibitory SS and VIP. In addition, PFPFE alleviated perirectal redness and hemorrhage in hemorrhoid mice, and downregulated levels of the serum inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β). In this study, we also analyzed the main active components and core targets of PFPFE for alleviating constipation and hemorrhoids through network pharmacology, and predicted its mechanism of action. Finally, we carried out Western blot experiments to verify that PFPFE and its active component kae alleviates constipation and hemorrhoids in mice by downregulating ESR1 and PI3K/Akt pathways. These results provide a scientific basis for the development of PFPFE as a functional food for alleviating constipation and hemorrhoids.
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