Tidal Volume, Positive End-expiratory Pressure, and Postoperative Hypoxemia: Comment

Correspondence| August 2023 Tidal Volume, Positive End-expiratory Pressure, and Postoperative Hypoxemia: Comment Aiman Suleiman, M.D., M.Sc.; Aiman Suleiman, M.D., M.Sc. Search for other works by this author on: This Site PubMed Google Scholar Elias Baedorf-Kassis, M.D.; Elias Baedorf-Kassis, M.D. Search for other works by this author on: This Site PubMed Google Scholar Daniel Talmor, M.D., M.P.H.; Daniel Talmor, M.D., M.P.H. Search for other works by this author on: This Site PubMed Google Scholar Maximilian Sebastian Schaefer, MD., Ph.D. Maximilian Sebastian Schaefer, MD., Ph.D. 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (M.S.S.). msschaef@bidmc.harvard.edu Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information (Accepted for publication February 16, 2023. Published online first on May 10, 2023.) Anesthesiology August 2023, Vol. 139, 232–233. https://doi.org/10.1097/ALN.0000000000004554 Connected Content Article: Tidal Volume and Positive End-expiratory Pressure and Postoperative Hypoxemia during General Anesthesia: A Single-center Multiple Crossover Factorial Cluster Trial Reply: Tidal Volume, Positive End-expiratory Pressure, and Postoperative Hypoxemia: Reply Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Aiman Suleiman, Elias Baedorf-Kassis, Daniel Talmor, Maximilian Sebastian Schaefer; Tidal Volume, Positive End-expiratory Pressure, and Postoperative Hypoxemia: Comment. Anesthesiology 2023; 139:232–233 doi: https://doi.org/10.1097/ALN.0000000000004554 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll PublicationsAnesthesiology Search Advanced Search We read the article by Turan et al.1 with great interest and would like to congratulate the authors on conducting this large, important, factorial trial. The authors found that neither a “high” (8 cm H2O) positive end-expiratory pressure (PEEP), nor a low (6 ml/kg) tidal volume strategy or a combination impacted postextubation hypoxemia or postoperative pulmonary complications. As such, the trial confirms findings of previous studies2 that nonindividualized PEEP levels do not improve patient outcomes. It corroborates findings from a large study by Karalapillai et al.3 that simply randomizing to high versus low tidal volumes does not seem to confer benefit for patients undergoing mechanical ventilation for general anesthesia. We would like to add two important observations based on recent literature to the discussion of the study by Turan et al.1 First, Neto et al.4 and others have shown that it is not... You do not currently have access to this content.