Intra‐ and Peritumoral Based Radiomics for Assessment of Lymphovascular Invasion in Invasive Breast Cancer

医学 列线图 淋巴血管侵犯 无线电技术 有效扩散系数 乳腺癌 接收机工作特性 磁共振成像 乳房磁振造影 放射科 磁共振弥散成像 核医学 癌症 肿瘤科 转移 乳腺摄影术 内科学
作者
Wenyan Jiang,Ruiqing Meng,Yuan Cheng,Haotian Wang,Tingting Han,Ning Qu,Tao Yu,Yang Hou,Shu Xu
出处
期刊:Journal of Magnetic Resonance Imaging [Wiley]
卷期号:59 (2): 613-625 被引量:25
标识
DOI:10.1002/jmri.28776
摘要

Background Radiomics has been applied for assessing lymphovascular invasion (LVI) in patients with breast cancer. However, associations between features from peritumoral regions and the LVI status were not investigated. Purpose To investigate the value of intra‐ and peritumoral radiomics for assessing LVI, and to develop a nomogram to assist in making treatment decisions. Study Type Retrospective. Population Three hundred and sixteen patients were enrolled from two centers and divided into training ( N = 165), internal validation ( N = 83), and external validation ( N = 68) cohorts. Field Strength/Sequence 1.5 T and 3.0 T/dynamic contrast‐enhanced (DCE) and diffusion‐weighted imaging (DWI). Assessment Radiomics features were extracted and selected based on intra‐ and peritumoral breast regions in two magnetic resonance imaging (MRI) sequences to create the multiparametric MRI combined radiomics signature (RS‐DCE plus DWI). The clinical model was built with MRI‐axillary lymph nodes (MRI ALN), MRI‐reported peritumoral edema (MPE), and apparent diffusion coefficient (ADC). The nomogram was constructed with RS‐DCE plus DWI, MRI ALN, MPE, and ADC. Statistical Tests Intra‐ and interclass correlation coefficient analysis, Mann–Whitney U test, and least absolute shrinkage and selection operator regression were used for feature selection. Receiver operating characteristic and decision curve analyses were applied to compare performance of the RS‐DCE plus DWI, clinical model, and nomogram. Results A total of 10 features were found to be associated with LVI, 3 from intra‐ and 7 from peritumoral areas. The nomogram showed good performance in the training (AUCs, nomogram vs. clinical model vs. RS‐DCE plus DWI, 0.884 vs. 0.695 vs. 0.870), internal validation (AUCs, nomogram vs. clinical model vs. RS‐DCE plus DWI, 0.813 vs. 0.695 vs. 0.794), and external validation (AUCs, nomogram vs. clinical model vs. RS‐DCE plus DWI, 0.862 vs. 0.601 vs. 0.849) cohorts. Data Conclusion The constructed preoperative nomogram might effectively assess LVI. Level of Evidence 3 Technical Efficacy Stage 2
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
共享精神应助橘笙采纳,获得10
1秒前
耍酷问兰发布了新的文献求助10
2秒前
科研通AI2S应助nczpf2010采纳,获得10
4秒前
搜集达人应助杜兰特工队采纳,获得10
9秒前
热心市民小红花应助牛马采纳,获得10
11秒前
热心市民小红花应助牛马采纳,获得10
11秒前
11秒前
Ava应助WJM采纳,获得10
15秒前
科研通AI2S应助nczpf2010采纳,获得10
16秒前
酷酷飞烟发布了新的文献求助10
16秒前
Bressanone发布了新的文献求助10
18秒前
李健的小迷弟应助老吴采纳,获得10
18秒前
大气的雅山完成签到,获得积分10
20秒前
shaoshao86完成签到,获得积分10
26秒前
26秒前
华仔应助科研通管家采纳,获得10
26秒前
逆时针应助科研通管家采纳,获得10
26秒前
MchemG应助科研通管家采纳,获得10
26秒前
研友_VZG7GZ应助科研通管家采纳,获得10
26秒前
wang应助科研通管家采纳,获得10
26秒前
wang应助科研通管家采纳,获得10
26秒前
ding应助科研通管家采纳,获得10
26秒前
上官若男应助科研通管家采纳,获得10
27秒前
思源应助科研通管家采纳,获得10
27秒前
田様应助科研通管家采纳,获得10
27秒前
小北发布了新的文献求助10
27秒前
NexusExplorer应助Quinna采纳,获得10
29秒前
30秒前
30秒前
量子星尘发布了新的文献求助10
32秒前
WJM发布了新的文献求助10
36秒前
老吴发布了新的文献求助10
37秒前
38秒前
佳语妍说完成签到,获得积分10
39秒前
40秒前
41秒前
酷波er应助平淡的凝竹采纳,获得10
42秒前
44秒前
小星星发布了新的文献求助10
44秒前
田様应助c_123采纳,获得10
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989069
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253589
捐赠科研通 3269939
什么是DOI,文献DOI怎么找? 1804851
邀请新用户注册赠送积分活动 882074
科研通“疑难数据库(出版商)”最低求助积分说明 809073