活性氧
癌细胞
谷胱甘肽
脂质过氧化
蛭石
癌症研究
纳米载体
过氧化氢
纳米医学
GPX4
化学
材料科学
细胞生物学
抗氧化剂
癌症
生物化学
生物
纳米技术
纳米颗粒
酶
谷胱甘肽过氧化物酶
复合材料
遗传学
作者
Lifang Ma,Hui Huang,Wei Feng,Liang Chen,Lili Xia,Yongchun Yu,Jiayi Wang,Yu Chen
标识
DOI:10.1002/adfm.202208220
摘要
Abstract The emerging chemodynamic therapy employs an iron‐based catalytic Fenton reaction to transform less‐reactive endogenous hydrogen peroxide within the tumor microenvironment (TME) into a highly toxic hydroxyl radical for killing cancer cells. However, the effective deployment of chemodynamic modality remains challenging, mired by a paucity of Fenton agents and overexpressed antioxidant glutathione (GSH) in cancer cells. Herein, a clay‐based 2D vermiculite nanosheet as a self‐reinforcing chemodynamic nanoagent for efficient lung cancer treatment is engineered. The engineered 2D vermiculite nanosheets are not only biocompatible with normal cells but also capable of regulating the TME through depleting GSH, which ameliorates the antioxidant activity of cancer cells. Meanwhile, GSH consumption results in increased intracellular reactive oxygen species content and enhanced lipid peroxidation level, thus inducing ferroptosis and augmenting chemodynamic cell‐killing efficacy. In particular, the ferrous oxidase hephaestin is the direct therapeutic target for 2D vermiculite nanosheets to fight against lung cancer cells. Systematic in vivo evaluations on a xenografted tumor model verify the favorable biosafety and effective tumor suppression capacity of the engineered 2D vermiculite nanosheets‐mediated chemodynamic tumor therapy by inducing desirable ferroptosis. Therefore, the developed vermiculite nanosheets represent the paradigm of 2D ferroptosis‐inducing nanomedicine for synergistic and efficient cancer treatment.
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