急性肾损伤
肾脏疾病
医学
病态的
重症监护医学
机制(生物学)
肾功能
疾病
肾
生物信息学
内科学
生物
认识论
哲学
作者
Runzhi Guo,Jiayu Duan,Shaokang Pan,Fei Cheng,Yingjin Qiao,Qi Feng,Dongwei Liu,Zhangsuo Liu
标识
DOI:10.1038/s41419-023-05969-9
摘要
Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a precipitous decline in renal function. In recent years, a growing body of studies have demonstrated that renal maladaptation following AKI results in chronic kidney disease (CKD). Therefore, targeting the transition of AKI to CKD displays excellent therapeutic potential. However, the mechanism of AKI to CKD is mediated by multifactor, and there is still a lack of effective treatments. Ferroptosis, a novel nonapoptotic form of cell death, is believed to have a role in the AKI to CKD progression. In this study, we retrospectively examined the history and characteristics of ferroptosis, summarized ferroptosis's research progress in AKI and CKD, and discussed how ferroptosis participates in regulating the pathological mechanism in the progression of AKI to CKD. Furthermore, we highlighted the limitations of present research and projected the future evolution of ferroptosis. We hope this work will provide clues for further studies of ferroptosis in AKI to CKD and contribute to the study of effective therapeutic targets to prevent the progression of kidney diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI