EC50型
稻黄单胞菌
体内
抗菌活性
活性氧
效力
体外
细菌
丁香假单胞菌
诱导剂
化学
最低杀菌浓度
微生物学
生物化学
生物
最小抑制浓度
病菌
生物技术
遗传学
基因
作者
Hongwu Liu,Shanshan Su,Siyue Ma,Ting Li,Fang Wang,Yue Ding,Shi‐Tao Liu,Junrong Zhang,Hongmei Xiang,Xiang Zhou,Song Yang
标识
DOI:10.1021/acs.jafc.3c02615
摘要
Nowadays, reactive oxygen species (ROS) have been acknowledged as promising bactericidal targets against pesticide-resistant bacteria. Herein, to further excavate more excellent ROS inducers, simple 1,2,3,4-tetrahydro-β-carboline derivatives containing a 3-aminopropanamide moiety were prepared and assessed for their antibacterial potency. Notably, three promising compounds displayed significant antibacterial potency. Compound I29 exhibits excellent in vitro bioactivity, with an EC50 value of 5.73 μg/mL, and admirable in vivo activities (protective activity of 55.74% and curative activity of 65.50%) toward Xanthomonas oryzae pv. oryzae. Compound I16 has good activity in vitro, with an EC50 of 3.43 μg/mL, and outstanding bioactivities in vivo (protective activity of 92.50% and curative activity of 59.68%) against Xanthomonas axonopodis pv. citri. Compound I6 shows excellent in vitro bioactivity (EC50 = 2.86 μg/mL) and significant protective activity (94.02%) for preventing Pseudomonas syringae pv. actinidiae. Antibacterial mechanism investigations indicate that these compounds disrupt the balance of the redox system to kill bacteria. These simple 1,2,3,4-tetrahydro-β-carboline derivatives are promising leads to the discovery of bactericidal agents.
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