5-HT1A and 5-HT2A receptor effects on recognition memory, motor/exploratory behaviors, emotionality and regional dopamine transporter binding in the rat

5-HT1A受体 多巴胺 心理学 神经科学 多巴胺转运体 情绪性 血清素转运体 识别记忆 受体 血清素 5-羟色胺受体 内科学 多巴胺能 医学 认知
作者
Susanne Nikolaus,Owen Y. Chao,Jan Henke,Markus Beu,Benedetta Fazari,Filipe Rodrigues Almeida,Laila Abdel‐Hafiz,Christina Antke,Hubertus Hautzel,Eduards Mamlins,Hans‐Wilhelm Müller,Joseph P. Huston,Charlotte von Gall,Frederik L. Giesel
出处
期刊:Behavioural Brain Research [Elsevier BV]
卷期号:: 115051-115051
标识
DOI:10.1016/j.bbr.2024.115051
摘要

Both dopamine (DA) and serotonin (5-HT) play key roles in numerous functions including motor control, stress response and learning. So far, there is scarce or conflicting evidence about the effects of 5-HT1A and 5-HT2A receptor (R) agonists and antagonists on recognition memory in the rat. This also holds for their effect on cerebral DA as well as 5-HT release. In the present study, we assessed the effects of the 5-HT1AR agonist 8-OH-DPAT and antagonist WAY100,635 and the 5-HT2AR agonist DOI and antagonist altanserin (ALT) on rat behaviors. Moreover, we investigated their impact on monoamine efflux by measuring monoamine transporter binding in various regions of the rat brain. After injection of either 8-OH-DPAT (3 mg/kg), WAY100,635 (0.4 mg/kg), DOI (0.1 mg/kg), ALT (1 mg/kg) or the respective vehicle (saline, DMSO), rats underwent an object and place recognition memory test in the open field. Upon the assessment of object exploration, motor/exploratory parameters and feces excretion, rats were administered the monoamine transporter radioligand N-o-fluoropropyl-2b-carbomethoxy-3b-(4-[123I]iodophenyl)-nortropane ([123I]-FP-CIT; 8.9 ± 2.6 MBq) into the tail vein. Regional radioactivity accumulations in the rat brain were determined post mortem. Compared to the controls, administration of 8-OH-DPAT impaired memory for place, decreased rearing behavior, and increased ambulation as well as head-shoulder movements. DOI administration led to a reduction in rearing behavior but an increase in head-shoulder motility relative to vehicle. Feces excretion was diminished after ALT relative to vehicle. Dopamine transporter (DAT) binding was increased in the caudateputamen (CP), but decreased in the nucleus accumbens (NAC) after 8-OH-DPAT relative to vehicle. Moreover, DAT binding was decreased in the NAC after ALT relative to vehicle. Findings indicate that 5-HT1AR inhibition and 5-HT2AR activation may impair memory for place. Furthermore, results imply associations not only between recognition memory, motor/exploratory behavior and emotionality but also between the respective parameters and the levels of available DA in CP and NAC.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
顾矜应助宋嘉佳采纳,获得10
1秒前
songyk完成签到,获得积分10
1秒前
隐形曼青应助man采纳,获得10
1秒前
NexusExplorer应助大力的源智采纳,获得10
1秒前
迷路的小之完成签到,获得积分10
1秒前
1111chen发布了新的文献求助10
1秒前
1秒前
2秒前
斯文败类应助大胆金针菇采纳,获得10
2秒前
呼呼呼完成签到,获得积分10
2秒前
zzzzzzzzzzzzx发布了新的文献求助10
3秒前
沧海泪发布了新的文献求助10
3秒前
韶绍完成签到 ,获得积分10
4秒前
烟花应助爱德华采纳,获得10
5秒前
研友_LweedZ发布了新的文献求助10
5秒前
NexusExplorer应助gjy采纳,获得10
5秒前
番fan完成签到,获得积分10
6秒前
6秒前
万能图书馆应助youyyuy采纳,获得10
6秒前
岛屿域完成签到,获得积分10
6秒前
wwww完成签到,获得积分10
7秒前
8秒前
8秒前
8秒前
8秒前
ma完成签到,获得积分10
8秒前
8秒前
杨禄圆应助研友_LweedZ采纳,获得10
8秒前
9秒前
9秒前
suiting完成签到,获得积分10
10秒前
11秒前
沉默的孤菱完成签到,获得积分10
11秒前
脑洞疼应助李大海采纳,获得10
11秒前
汉堡包应助啊啊啊啊啊啊采纳,获得10
11秒前
12秒前
12秒前
12秒前
ahdai完成签到,获得积分10
12秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
晶种分解过程与铝酸钠溶液混合强度关系的探讨 8888
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Leading Academic-Practice Partnerships in Nursing and Healthcare: A Paradigm for Change 800
Signals, Systems, and Signal Processing 610
The Sage Handbook of Digital Labour 600
汪玉姣:《金钱与血脉:泰国侨批商业帝国的百年激荡(1850年代-1990年代)》(2025) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 工程类 有机化学 化学工程 生物化学 计算机科学 物理 内科学 复合材料 催化作用 物理化学 光电子学 电极 细胞生物学 基因 无机化学
热门帖子
关注 科研通微信公众号,转发送积分 6415501
求助须知:如何正确求助?哪些是违规求助? 8234628
关于积分的说明 17487344
捐赠科研通 5468527
什么是DOI,文献DOI怎么找? 2889128
邀请新用户注册赠送积分活动 1866019
关于科研通互助平台的介绍 1703611