铲斗
医学
尿酸
置信区间
内科学
炎症
C反应蛋白
血压
中性粒细胞与淋巴细胞比率
动态血压
白蛋白
胃肠病学
内分泌学
心脏病学
淋巴细胞
作者
Kaya Özen,Kenan Toprak,Mesut Karataş,A. Dursun
出处
期刊:Blood Pressure Monitoring
[Ovid Technologies (Wolters Kluwer)]
日期:2024-05-22
标识
DOI:10.1097/mbp.0000000000000709
摘要
Objective Physiologically, at night, blood pressure (BP) is expected to decrease by at least 10% in hypertensive individuals. The absence of this decrease, called non-dipper hypertension, is associated with increased end-organ damage and cardiovascular mortality and morbidity in hypertensive individuals. It is known that increased inflammatory process plays an important role in the etiopathogenesis of non-dipper hypertension pattern. In recent years, it has been shown that inflammation-based markers (IBMs) obtained by combining various inflammation-related hematological and biochemical parameters in a single fraction have stronger predictive value than single inflammatory parameters. However, until now, there has not been a study investigating the relationship of these markers with dipper/non-dipper status in newly diagnosed hypertensive patients. Methods Based on ambulatory BP monitoring, 217 dipper and 301 non-dipper naive hypertensive subjects were included in this study. All subjects’ IBM values were compared between dipper and non-dipper hypertensive individuals. Results IBMs [C-reactive protein/albumin ratio (CAR), monocyte/high-density lipoprotein cholesterol ratio (MHR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio, systemic immune-inflammation index (SII), uric acid/albumin ratio (UAR)] were significantly higher in the non-dipper group. CAR, MHR, NLR, SII, and UAR were determined as independent predictors for non-dipper pattern ( P < 0.05, for all). Also, UAR’s diagnostic performance for non-dipper pattern was found to be superior to other IBMs (area under the curve: 0.783, 95% confidence interval: 0.743–0.822; P < 0.001). Conclusion These findings suggest an association between elevated IBMs, particularly UAR, and the non-dipper hypertension pattern observed in our study.
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