Distinct gut microbiota and metabolite profiles induced by delivery mode in healthy Chinese infants

代谢物 肠道菌群 生物 计算生物学 微生物学 免疫学 生物化学
作者
Na Li,Shengnan Liang,Qingxue Chen,Lina Zhao,Bailiang Li,Guicheng Huo
出处
期刊:Journal of Proteomics [Elsevier BV]
卷期号:232: 104071-104071 被引量:28
标识
DOI:10.1016/j.jprot.2020.104071
摘要

Delivery mode is recognized as an important determinant of gut microbiota composition. Vaginally delivered infants were colonized by maternal vaginal and fecal microbiota, while those delivered by cesarean section were colonized by environmental microorganisms. To reveal differences induced by delivery mode, we determined fecal microbiota and fecal metabolome from 60 infants in Northeast China region. Bacterial gene sequence analysis showed that the feces of vaginally delivered infants had the highest abundance of Bifidobacterium, Lactobacillus, Bacteroides and Parabacteroides, while the feces of cesarean section delivered infants were more enriched in Klebsiella. LC-MS-based metabolomics data demonstrated that the feces of vaginally delivered infants were associated with high abundance of DL-norvaline and DL-citrulline, while the feces of cesarean section delivered infants were abundant in trans-vaccenic acid and cis-aconitic acid. Moreover, the feces of vaginally delivered infants was significantly in positive correlation with tryptophan metabolism and pyruvate metabolism, however, the feces of cesarean section delivered infants was positively correlated with ABC transporters. Collectively, our study demonstrated that gut microbiota and metabolite profiles were significantly different between vaginally delivered and cesarean section delivered infants, and provided the theoretical basis for restoring the intestinal environment of cesarean section infants birthed in the study region. The intestinal microbiota and metabolites play important roles in infant development. To validate whether delivery modes influence the gut environment, we performed a detailed analysis of the earliest microbial colonization of the infant gut using a combination of 16S rRNA gene amplicon sequencing and LC-MS-based metabolomics. We found that the gut microbiota and metabolite composition were significantly different between vaginally delivered infants and cesarean section delivered infants. Our findings establish a vital baseline for studies tracking the infant gut microbiota and metabolite development following different delivery modes, and their associated effects on infant health. This study provides preliminary evidence that the observed differences due to delivery modes highlight their importance in shaping the early intestinal microbiota and metabolites.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
EXO发布了新的文献求助10
刚刚
刚刚
李远哲完成签到,获得积分10
1秒前
1秒前
1秒前
1秒前
2秒前
可爱的函函应助风清扬采纳,获得10
2秒前
好好发布了新的文献求助10
3秒前
ww完成签到,获得积分10
4秒前
打打应助虾米采纳,获得10
4秒前
贰叁发布了新的文献求助10
5秒前
Inory007发布了新的文献求助10
6秒前
隐形曼青应助未道采纳,获得10
7秒前
小周发布了新的文献求助10
7秒前
ZDY完成签到,获得积分10
8秒前
NL14D发布了新的文献求助10
9秒前
9秒前
Owen应助wztin采纳,获得10
14秒前
Nxxxxxx发布了新的文献求助10
14秒前
15秒前
FIN应助默默的彩虹采纳,获得30
15秒前
16秒前
天南完成签到,获得积分10
16秒前
17秒前
19秒前
20秒前
李远哲发布了新的文献求助10
21秒前
发发发布了新的文献求助10
22秒前
vigour发布了新的文献求助10
24秒前
25秒前
星辰大海应助丰富幻悲采纳,获得10
26秒前
jcduoduo完成签到,获得积分10
26秒前
26秒前
斯文败类应助轻松的若南采纳,获得10
27秒前
ronnie完成签到,获得积分10
27秒前
28秒前
奋斗雁山发布了新的文献求助30
29秒前
yyyych发布了新的文献求助20
30秒前
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988838
求助须知:如何正确求助?哪些是违规求助? 3531250
关于积分的说明 11252914
捐赠科研通 3269838
什么是DOI,文献DOI怎么找? 1804820
邀请新用户注册赠送积分活动 881943
科研通“疑难数据库(出版商)”最低求助积分说明 809028