Carbostyril derivatives: Synthesis of novel carbostyril-3′-carbonitrilselenophene hybrid compounds and investigation of their antiproliferative properties on prostate and breast cancer

To synthesize a new series of carbostyril-3′-carbonitrilselenophene hybrid compounds, Pechmann coumarin compounds were reacted with 2-amino-3′-carbonitrilselenophene derivatives and their anticancer activities on MCF7 and DU145 cell lines and antioxidant activities were investigated. Anticancer and antioxidant activities of the starting compounds and their corresponding new hybrid compounds were compared. It was determined that IC50 values of hybrid compounds (3e, 3f, 3g, and 3h) on the MCF7 breast cancer cell line showed the highest cytotoxic activity with 7.99, 3.64, 7.72, and 2.74 µM values, respectively. In the case of anticancer activity on the DU145 prostate cancer cell line, compounds 3f and 3h were found to have the highest cytotoxic activity with IC50 values of 4.21 and 3.90 µM, respectively. The compound 3g is also the most radical scavenging compound with an inhibition value of 88.78%.