小RNA
生物
微泡
竞争性内源性RNA
计算生物学
环状RNA
乳腺癌
功能(生物学)
核糖核酸
癌症
鉴定(生物学)
生物信息学
长非编码RNA
遗传学
基因
植物
作者
Su-Jin Yang,Dandan Wang,Siying Zhou,Qian Zhang,Jinyan Wang,Shanliang Zhong,Heda Zhang,Xingyun Wang,Xiaojing Xing,Wei Chen,Shumei Yang,Jiahua Hu,Jinmin Zhao,Jinhai Tang
出处
期刊:Epigenomics
[Future Medicine]
日期:2020-01-01
卷期号:12 (2): 101-125
被引量:31
标识
DOI:10.2217/epi-2019-0058
摘要
Aim: Circular RNAs (circRNAs) still have many potential functions in the process of tumor development that are not completely understood. The study aims to explore novel circRNAs and their mechanisms of action in breast cancer (BCa). Materials & methods: A combination strategy of RNA-sequencing (RNA-seq) technique, quantitative real-time PCR and bioinformatic analysis was employed to identify the potential mechanisms involving differentially expressed circRNAs in the serum exosomes and tissues of BCa patients. Results: The expression levels of hsa-circRNA-0005795 and hsa-circRNA-0088088 were significantly different both in serum exosomes and tissues and might function as competing endogenous RNAs and play vital roles in BCa development. Conclusion: We constructed two circRNA–miRNA networks and provided new insight into the prognosis and therapy of BCa using circRNAs from serum exosomes.
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