[High serum cholesterol: a novel risk factor for thyroid associated ophthalmopathy?]

This study was aimed to investigate the association between dyslipidemia and thyroid associated ophthalmopathy (TAO). We evaluated the relationship between dyslipidemia and TAO in 218 patients with Graves' disease (GD) and found that the serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in the GD subjects with TAO (n=110) were significantly increased [(5.32±1.39) mmol/L vs. (3.18±2.12) mmol/L, (2.98±0.75) mmol/L vs. (1.25±0.98) mmol/L] than those in the GD subjects without TAO (n=108). TC and LDL-C were positively correlated with the Clinical disease activity score (CAS) [TC (r=0.7, P=0.03),LDL-C (r=0.82, P=0.03)], and the levels of TC (OR=2.56, P=0.02) and LDL-C(OR=2.01, P=0.015) were positively associated with TAO. These suggested that high serum cholesterol level is a novel risk factor for TAO, and management of blood lipids should be included in the treatment of TAO.初步探讨血脂异常与甲状腺相关性眼病（TAO）的发病关系。评估218例初发Graves病患者血脂异常与TAO发病的关系。结果显示，合并TAO组的血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）明显高于单纯Graves病组[(5.32±1.39)mmol/L比（3.18±2.12)mmol/L；(2.98±0.75)mmol/L比（1.25±0.98)mmol/L]，且与临床疾病活动分数（CAS）呈正相关[TC(r=0.7, P=0.03)、LDL-C(r=0.82, P=0.03)]；TAO的发病与TC(OR=2.56,P=0.02)、LDL-C(OR=2.01,P=0.015）水平均明显相关。提示高胆固醇水平与TAO的发病有关，可能是TAO发病的一个新的危险因素，提示TAO的治疗还应关注血脂的管理。.