Nerve input to tumours: Pathophysiological consequences of a dynamic relationship

癌症 迷走神经 前列腺癌 旁侵犯 癌细胞 病理 神经科学 癌变 前列腺 生物 胰腺癌 医学 内科学 刺激
作者
Charlotte Hutchings,Jade A. Phillips,Mustafa B.A. Djamgoz
出处
期刊:Biochimica Et Biophysica Acta - Reviews On Cancer [Elsevier]
卷期号:1874 (2): 188411-188411 被引量:60
标识
DOI:10.1016/j.bbcan.2020.188411
摘要

It is well known that tumours arising in different organs are innervated and that ‘perineural invasion’ (cancer cells escaping from the tumour by following the nerve trunk) is a negative prognostic factor. More surprisingly, increasing evidence suggests that the nerves can provide active inputs to tumours and there is two-way communication between nerves and cancer cells within the tumour microenvironment. Cells of the immune system also interact with the nerves and cancer cells. Thus, the nerve connections can exert significant control over cancer progression and modulating these (physically or chemically) can affect significantly the cancer process. Nerve inputs to tumours are derived mainly from the sympathetic (adrenergic) and the parasympathetic (cholinergic) systems, which are interactive. An important component of the latter is the vagus nerve, the largest of the cranial nerves. Here, we present a two-part review of the nerve inputs to tumours and their effects on tumorigenesis. First, we review briefly some relevant general issues including ultrastructural aspects, stemness, interactions between neurones and primary tumours, and communication between neurones and metastasizing tumour cells. Ultrastructural characteristics include synaptic vesicles, tumour microtubes and gap junctions enabling formation of cellular networks. Second, we evaluate the pathophysiology of the nerve input to five major carcinomas: cancers of prostate, stomach, colon, lung and pancreas. For each cancer, we present (i) the nerve inputs normally present in the cancer organ and (ii) how these interact and influence the cancer process. The best clinical evidence for the role of nerves in promoting tumorigenesis comes from prostate cancer patients where metastatic progression has been shown to be suppressed significantly in cases of spinal cord injury. The balance of the sympathetic and parasympathetic contributions to early versus late tumorigenesis varies amongst the different cancers. Different branches of the vagus provide functional inputs to several of the carcinomas and, in two-way interaction with the sympathetic nervous system, affect different stages of the cancer process. Overall, the impact of the vagus nerve can be ‘direct’ or ‘indirect’. Directly, the effect of the vagus is primarily to promote tumorigenesis and this is mediated through cholinergic receptor mechanisms. Indirectly, pro- and anti-tumour effects can occur by stimulation or inhibition of the sympathetic nervous system, respectively. Less well understood are the ‘indirect’ anti-tumour effect of the vagus nerve via immunomodulation/inflammation, and the role of sensory innervation. A frequent occurrence in the nerve-tumour interactions is the presence of positive feedback driven by agents like nerve growth factor. We conclude that the nerve inputs to tumours can actively and dynamically impact upon cancer progression and are open to clinical exploitation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
芷兰丁香发布了新的文献求助10
2秒前
3秒前
体贴的兔子完成签到,获得积分10
3秒前
5秒前
冷静凌旋完成签到,获得积分10
7秒前
Ava应助小凉采纳,获得10
8秒前
甩看文献发布了新的文献求助10
8秒前
8秒前
9秒前
尊敬曼岚发布了新的文献求助10
10秒前
杨青月发布了新的文献求助10
10秒前
jing发布了新的文献求助10
13秒前
13秒前
甩看文献完成签到,获得积分10
14秒前
16秒前
18秒前
巴山石也完成签到 ,获得积分10
19秒前
唐帅完成签到,获得积分10
19秒前
万能图书馆应助廉紫真采纳,获得10
20秒前
千秋梧发布了新的文献求助10
22秒前
领导范儿应助WW采纳,获得10
24秒前
cecilia发布了新的文献求助50
27秒前
27秒前
专一发布了新的文献求助10
28秒前
30秒前
32秒前
杨青月完成签到,获得积分10
32秒前
32秒前
33秒前
鱼咬羊发布了新的文献求助10
33秒前
34秒前
NexusExplorer应助jing采纳,获得10
35秒前
子车茗应助Cynthia采纳,获得30
36秒前
bobo发布了新的文献求助10
37秒前
爱吃年糕发布了新的文献求助10
38秒前
39秒前
深情安青应助尊敬曼岚采纳,获得10
40秒前
拉蒙达完成签到,获得积分10
40秒前
41秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2000
Very-high-order BVD Schemes Using β-variable THINC Method 1200
BIOLOGY OF NON-CHORDATES 1000
进口的时尚——14世纪东方丝绸与意大利艺术 Imported Fashion:Oriental Silks and Italian Arts in the 14th Century 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 550
Zeitschrift für Orient-Archäologie 500
The Collected Works of Jeremy Bentham: Rights, Representation, and Reform: Nonsense upon Stilts and Other Writings on the French Revolution 320
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3352392
求助须知:如何正确求助?哪些是违规求助? 2977572
关于积分的说明 8680222
捐赠科研通 2658516
什么是DOI,文献DOI怎么找? 1455863
科研通“疑难数据库(出版商)”最低求助积分说明 674139
邀请新用户注册赠送积分活动 664679