Experimental Study of Regeneration of the Denervated Muscle Transplantation in Rabbits

Objective:To investigate the regeneration of the denervated transplantation muscles.Methods:The regeneration of musculus flexor digitorum profundus as a pedicled graft after the median nerve dissection on rabbit models was studied by histology,histochemistry,electromicroseopy and electromyogram at different intervals after operation.Results:Degeneration and patchy necrosis of the muscle appeared on the 14th day and reached the climax on the 30th day.The regeneration followed and almost completed on the 90th day by the continuous and discontinuous patterns.In the regenerated muscle fiber arrangements,grouping pattern predominated over the mosaic pattern on the 90th and 180th days after operation.EMG showed potential action in 90 days as a sign of muscle contraction and functional recovery.Conclusions:Satisfactory morpholo gic and functional recovery of the transplanted muscles can be seen in experimental models.So denervated muscular transplantation can be used as a reliable procedure in clinical practice. Key words: Muscle denervation; Muscles; Transplantation,homologous