化学
化学合成
分子
全合成
聚吡咯
组合化学
立体化学
有机化学
生物化学
聚合
体外
聚合物
作者
Karl T. Haelsig,Jun Xuan,Thomas J. Maimone
摘要
Curvulamine and related polypyrrole alkaloids represent a fascinating new class of natural products with unprecedented chemical structures, intriguing biological activities, and mysterious biosynthetic origins. Herein we report the first studies toward these molecules, resulting in a 10-step total synthesis of (−)-curvulamine, a dimeric member with promising Gram-positive and -negative antibiotic activity. A number of interesting chemical findings, including exploitation of the heteroaromatic pyrrolo[1,2-a]azepinone nucleus and an efficient stereodivergent reduction, are reported.
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