A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

Pyroptosis is a unique form of programmed cell death that is essentially proinflammatory and critical for immunity. In their Research Article(e202115800), Qian Cao, Zong-Wan Mao, and co-workers developed a carbonic anhydrase IX (CAIX)-anchored photosensitizer, CA-Re, that is capable of inducing and self-reporting membrane rupture upon irradiation, as well as evoking pyroptosis to activate antitumor immunity. CA-Re is the first metal-complex-based pyroptosis inducer, and this work provides a promising avenue for cancer metalloimmunotherapy.