Interactions and toxicity of non-essential heavy metals (Cd, Pb and Hg): lessons from Drosophila melanogaster

Some heavy metals are essential in trace amounts, enhancing enzyme functioning and other intracellular molecules. Others are explicitly toxic at low concentrations, increasing the risk of organ-related toxicity. Non-essential metals have similar mechanisms of toxicity to essential metals. These include the modifiable change in oxidation states, interaction with sulfhydryl moieties of proteins and indirect modification of nucleic acids. Ultimately, oxidative stress is generated, and potentiation of damage ensues. The susceptibility, sensitivity, genetic resources, and cellular response of Drosophila melanogaster to heavy metal exposure and toxicity have made this insect appropriate for toxicological studies. In this review, we focus on the toxicological impacts of non-essential metals (Cd, Pb, and Hg) in Drosophila and discuss its cellular and developmental responses to increasing concentrations of these metals. We also suggest current or proposed therapeutic alternatives, as well as dimensions that may improve the studies of non-essential metal biology.