皮质基底变性
进行性核上麻痹
路易氏体型失智症
常压脑积水
医学
失智症
疾病
鉴别诊断
痴呆
病理
脑积水
帕金森病
神经科学
作者
Takuma Ohmichi,Takahiko Tokuda
出处
期刊:Neurological Surgery
日期:2022-03-01
卷期号:50 (2): 319-330
标识
DOI:10.11477/mf.1436204560
摘要
There are a variety of neurodegenerative diseases that require differentiation from idiopathic normal pressure hydrocephalus(iNPH), including Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration. As the clinical features and structural imaging findings of these diseases may overlap with iNPH, biomarkers reflecting disease-specific pathology are necessary for differential diagnosis. In addition, these diseases often coexist with iNPH in elderly patients, and it is important to confirm the coexistence of their pathology even in cases clinically diagnosed as iNPH. This review provides an overview of established and emerging biomarkers for neurodegenerative diseases.
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