区域选择性
串联
咔唑
组合化学
胺化
化学
基质(水族馆)
立体化学
催化作用
有机化学
生物
材料科学
生态学
复合材料
作者
Emma Campbell,Andrea Taladriz‐Sender,Olivia I. Paisley,Alan R. Kennedy,Jacob T. Bush,Glenn A. Burley
标识
DOI:10.1021/acs.joc.1c02943
摘要
A modular approach to prepare tri- and tetracyclic carbazoles by a sequential [3 + 2]heteroannulation is described. First, optimization of Pd-catalyzed Buchwald-Hartwig amination followed by C/N-arylation in a one-pot process is established. Second, mechanistic analyses identified the origins of chemo- and regioselective sequential control of both bond-forming steps. Finally, the substrate scope is demonstrated by the preparation of a range of tri- and tetracyclic carbazoles, including expedient access to several natural products and anti-cancer agents.
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