纳米载体
整合素
化学
血管生成
药物输送
癌症研究
药理学
毒品携带者
靶向给药
肽
医学
纳米技术
材料科学
受体
生物化学
作者
Kavita R. Gajbhiye,Virendra Gajbhiye,Imtiaz A. Siddiqui,J. M. Gajbhiye
标识
DOI:10.1080/1061186x.2018.1473409
摘要
The integrins αvβ3 play a very imperative role in angiogenesis and are overexpressed in endothelial cells of the tumour. Recent years have witnessed huge exploration in the field of αvβ3 integrin-mediated bioactive targeting for treatment of cancer. In these studies, the cRGD peptide has been employed extensively owing to their binding capacity to the αvβ3 integrin. Principally, RGD-based approaches comprise of antagonist molecules of the RGD sequence, drug–RGD conjugates, and most importantly tethering of the nanocarrier surface with the RGD peptide as targeting ligand. Targeting tumour vasculature or cells via cRGD conjugated nanocarriers have emerged as a promising technique for delivering chemotherapeutic drugs and imaging agents for cancer theranostics. In this review, primary emphasis has been given on the application of cRGD-anchored nanocarriers for targeted delivery of drugs, imaging agents, etc. for tumour therapy.
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