竞争性内源性RNA
生物
小RNA
计算生物学
环状RNA
癌症
癌症研究
核糖核酸
外显子
基因
细胞生物学
内含子
癌细胞
癌变
遗传学
转移
基因敲除
基因沉默
RNA干扰
生物信息学
抑制器
细胞生长
功能(生物学)
长非编码RNA
作者
Yaxian Zhong,Yajun Du,Xue Yang,Yongzhen Mo,Chunmei Fan,Fang Xiong,Daixi Ren,Xin Ye,Chunwei Li,Yumin Wang,Wei Fang,Can Guo,Xu Wu,Xiaoling Li,Yong Li,Guiyuan Li,Zhaoyang Zeng,Wei Xiong
标识
DOI:10.1186/s12943-018-0827-8
摘要
Circular RNAs (circRNAs) are connected at the 3′ and 5′ ends by exon or intron cyclization, forming a complete ring structure. circRNA is more stable and conservative than linear RNA and abounds in various organisms. In recent years, increasing numbers of reports have found that circRNA plays a major role in the biological functions of a network of competing endogenous RNA (ceRNA). circRNAs can compete together with microRNAs (miRNAs) to influence the stability of target RNAs or their translation, thus, regulating gene expression at the transcriptional level. circRNAs are involved in biological processes such as tumor cell proliferation, apoptosis, invasion, and migration as ceRNAs. circRNAs, therefore, represent promising candidates for clinical diagnosis and treatment. Here, we review the progress in studying the role of circRNAs as ceRNAs in tumors and highlight the participation of circRNAs in signal transduction pathways to regulate cellular functions.
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