Cu(III)-Mediated Aerobic Oxidations

CuIII species have been invoked in many copper-catalyzed transformations including cross-coupling reactions and oxidation reactions. In this review, we will discuss seminal discoveries that have advanced our understanding of the CuI/CuIII redox cycle in the context of C–C and C–heteroatom aerobic cross-coupling reactions, as well as C–H oxidation reactions mediated by CuIII–dioxygen adducts. 1 General Introduction 2 Early Examples of CuIII Complexes 3 Aerobic CuIII-Mediated Carbon–Heteroatom Bond-Forming Reactions 4 Aerobic CuIII-Mediated Carbon–Carbon Bond-Forming Reactions 5 Bioinorganic Studies of CuIII Complexes from CuI and O2 5.1 O2 Activation 5.2 Biomimetic CuIII Complexes from CuI and Dioxygen 5.2.1 Type-3 Copper Enzymes and Dinuclear Cu Model Complexes 5.2.2 Particulate Methane Monooxygenase and Di- and Trinuclear Cu Model Complexes 5.2.3 Dopamine–β-Monooxygenase and Mononuclear Cu Model Complexes 6 Conclusion