姜黄素
PEG比率
生物膜
聚乙二醇
粘附
纳米复合材料
白色念珠菌
材料科学
纳米技术
生物分子
石墨烯
生物污染
化学
化学工程
膜
微生物学
有机化学
生物化学
复合材料
细菌
经济
工程类
生物
遗传学
财务
作者
Valentina Palmieri,Francesca Bugli,Margherita Cacaci,Giordano Perini,Flavio De Maio,Giovanni Delogu,Riccardo Torelli,Claudio Conti,Maurizio Sanguinetti,Marco De Spirito,R. Zanoni,Massimiliano Papi
出处
期刊:Nanomedicine
日期:2018-11-01
卷期号:13 (22): 2867-2879
被引量:56
标识
DOI:10.2217/nnm-2018-0183
摘要
Aim: Fabrication of graphene oxide (GO)-based medical devices coatings that limit adhesion of Candida albicans, a main issue of healthcare-associated infections. Methods: The GO composites noncovalently functionalized with curcumin (CU), a hydrophobic molecule with active antimicrobial action, polyethylene glycol (PEG) that hinders the absorption of biomolecules or a combination of CU and PEG (GO–CU–PEG) were drop-casted on surfaces and antifungal efficacy was assessed. Results: We demonstrate that GO–CU–PEG coatings can reduce fungal adhesion, proliferation and biofilm formation. Furthermore, in an aqueous environment, surfaces release curcumin–PEG nanocomposites that have a minimum inhibitory concentration of 9.25 μg/ml against C. albicans. Conclusion: Prevention of early cell adhesion and creation of a proximal environment unfavorable for growth make these GO-supported biomaterials attractive for innovative medical device manufacturing. [Formula: see text]
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