Abstract #117: Changes in high frequency activity depend on frequency of electrical stimulation in the human cortex

Brain stimulation shows enormous clinical potential as a treatment for a variety of neurological conditions; however, we do not yet have a detailed understanding of how stimulation alters underlying brain activity. In particular, there is only a fairly small literature on the how direct cortical brain stimulation has excitatory and inhibitory effects of stimulation on local and connected regions. We investigated the effects of direct electrical stimulation on the human brain to understand how changes in stimulation location, amplitude, frequency, and duration induce changes in activity across the brain. We collected human electrocorticographic recordings from neurosurgical patients while stimulation was systematically delivered for different combinations of stimulation location, amplitude, frequency, and duration. We calculated spectral power before and after the delivery of stimulation and mapped changes across the brain in the distribution of high frequency activity (30-100Hz) neural activity, which is a marker of mean neuronal activity.