光热治疗
体内
共轭体系
荧光
钆
磁共振成像
螯合作用
材料科学
荧光寿命成像显微镜
PEG比率
聚合物
化学
纳米技术
核磁共振
医学
光学
经济
复合材料
生物技术
放射科
冶金
物理
生物
财务
作者
Xiaoming Hu,Yufu Tang,Yuxuan Hu,Feng Lu,Xiaomei Lü,Yuqi Wang,Jie Li,Yuanyuan Li,Yu Ji,Wenjun Wang,Deju Ye,Quli Fan,Wei Huang
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2019-01-01
卷期号:9 (14): 4168-4181
被引量:117
摘要
Our exploiting versatile multimodal theranostic agent aims to integrate the complementary superiorities of photoacoustic imaging (PAI), second near-infrared (NIR-II, 1000-1700) fluorescence and T1-weighted magnetic resonance imaging (MRI) with an ultimate objective of perfecting cancer diagnosis, thus improving cancer therapy efficacy.Herein, we engineered and prepared a water-soluble gadolinium-chelated conjugated polymer-based theranostic nanomedicine (PFTQ-PEG-Gd NPs) for in vivo tri-mode PA/MR/NIR-II imaging-guided tumor photothermal therapy (PTT).Methods: We firstly constructed a semiconducting polymer composed of low-bandgap donor-acceptor (D-A) which afforded the strong NIR absorption for PAI/PTT and long fluorescence emission to NIR-II region for in vivo imaging.Then, the remaining carboxyl groups of the polymeric NPs could effectively chelate with Gd 3+ ions for MRI.The in vitro characteristics of the PFTQ-PEG-Gd NPs were studied and the in vivo multimode imaging as well as anti-tumor efficacy of the NPs was evaluated using 4T1 tumor-bearing mice.Results: The obtained theranostic agent showed excellent chemical and optical stability as well as low biotoxicity.After 24 h of systemic administration using PQTF-PEG-Gd NPs, the tumor sites of living mice exhibited obvious enhancement in PA, NIR-II fluorescence and positive MR signal intensities.Better still, a conspicuous tumor growth restraint was detected under NIR light irradiation after administration of PQTF-PEG-Gd NPs, indicating the efficient photothermal potency of the nano-agent.Conclusion: we triumphantly designed and synthesized a novel and omnipotent semiconducting polymer nanoparticles-based theranostic platform for PAI, NIR-II fluorescence imaging as well as positive MRI-guided tumor PTT in living mice.We expect that such a novel organic nano-platform manifests a great promise for high spatial resolution and deep penetration cancer theranostics.
科研通智能强力驱动
Strongly Powered by AbleSci AI