清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency

能量代谢 心功能曲线 功能(生物学) 心脏病学 内科学 环境科学 医学 生物 细胞生物学 心力衰竭
作者
Tariq Altamimi,Su Gao,Qutuba G. Karwi,Arata Fukushima,Sawan Kumar Rawat,Cory S. Wagg,Liyan Zhang,Gary D. Lopaschuk
出处
期刊:Metabolism-clinical and Experimental [Elsevier]
卷期号:98: 37-48 被引量:56
标识
DOI:10.1016/j.metabol.2019.06.005
摘要

Background Impaired cardiac insulin signalling and high cardiac fatty acid oxidation rates are characteristics of conditions of insulin resistance and diabetic cardiomyopathies. The potential role of liver-derived peptides such as adropin in mediating these changes in cardiac energy metabolism is unclear, despite the fact that in skeletal muscle adropin can preferentially promote glucose metabolism and improve insulin sensitivity. Objectives To determine the influence of adropin on cardiac energy metabolism, insulin signalling and cardiac efficiency. Methods C57Bl/6 mice were injected with either vehicle or a secretable form of adropin (450 nmol/kg, i.p.) three times over a 24-h period. The mice were fasted to accentuate the differences between animals in adropin plasma levels before their hearts were isolated and perfused using a working heart system. In addition, direct addition of adropin to the perfusate of ex vivo hearts isolated from non-fasting mice was utilized to investigate the acute effects of the peptide on heart metabolism and ex vivo function. Results In contrast to the observed fasting-induced predominance of fatty acid oxidation as a source of ATP production in control hearts, insulin inhibition of fatty acid oxidation was preserved by adropin treatment. Adropin-treated mouse hearts also showed a higher cardiac work, which was accompanied by improved cardiac efficiency and enhanced insulin signalling compared to control hearts. Interestingly, acute adropin administration to isolated working hearts also resulted in an inhibition of fatty acid oxidation, accompanied by a robust stimulation of glucose oxidation compared to vehicle-treated hearts. Adropin also increased activation of downstream cardiac insulin signalling. Moreover, both in vivo and ex vivo treatment protocols induced a reduction in the inhibitory phosphorylation of pyruvate dehydrogenase (PDH), the major enzyme of glucose oxidation, and the protein levels of the responsible kinase PDH kinase 4 and the insulin-signalling inhibitory phosphorylation of JNK (p-T183/Y185) and IRS-1 (p-S307), suggesting acute receptor- and/or post-translational modification-mediated mechanisms. Conclusions These results demonstrate that adropin has important effects on energy metabolism in the heart and may be a putative candidate for the treatment of cardiac disease associated with impaired insulin sensitivity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
mf2002mf完成签到 ,获得积分10
9秒前
11秒前
Hiaoliem完成签到 ,获得积分10
34秒前
52秒前
Kevin完成签到,获得积分20
57秒前
1分钟前
研友_LMg76Z发布了新的文献求助30
1分钟前
研友_LMg76Z完成签到,获得积分20
1分钟前
1分钟前
bookgg完成签到 ,获得积分10
1分钟前
龙猫爱看书完成签到,获得积分10
1分钟前
啵啵完成签到,获得积分10
1分钟前
拼搏的败完成签到 ,获得积分10
1分钟前
乐正怡完成签到 ,获得积分0
2分钟前
gobi完成签到 ,获得积分10
2分钟前
小乙猪完成签到 ,获得积分0
2分钟前
4inlove完成签到 ,获得积分10
2分钟前
2分钟前
三十四画生完成签到 ,获得积分10
2分钟前
lzx666完成签到,获得积分20
2分钟前
2分钟前
lzx666发布了新的文献求助10
2分钟前
madison完成签到 ,获得积分10
3分钟前
3分钟前
whitepiece完成签到,获得积分10
3分钟前
HCCha完成签到,获得积分10
3分钟前
科研通AI2S应助鼻揩了转去采纳,获得10
3分钟前
3分钟前
四叶草完成签到 ,获得积分10
4分钟前
4分钟前
迅速的蜡烛完成签到 ,获得积分10
4分钟前
5分钟前
铁妹儿完成签到 ,获得积分10
5分钟前
thchiang完成签到 ,获得积分10
5分钟前
英俊的铭应助飞翔的企鹅采纳,获得10
5分钟前
大模型应助volvoamg采纳,获得10
6分钟前
6分钟前
Wang完成签到 ,获得积分20
6分钟前
6分钟前
7分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
Idoxuridine 260
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196835
求助须知:如何正确求助?哪些是违规求助? 2845505
关于积分的说明 8054331
捐赠科研通 2510132
什么是DOI,文献DOI怎么找? 1342307
科研通“疑难数据库(出版商)”最低求助积分说明 639355
邀请新用户注册赠送积分活动 608669