恶唑酮
结肠炎
医学
免疫系统
免疫学
肠粘膜
内科学
作者
Benno Weigmann,Markus F. Neurath
出处
期刊:Methods in molecular biology
日期:2016-01-01
卷期号:: 253-261
被引量:19
标识
DOI:10.1007/978-1-4939-3603-8_23
摘要
Murine models of intestinal inflammation have been widely used in biomedical research. Similarities in anatomy and physiology between such murine models and patients with inflammatory bowel diseases may allow a better understanding of the pathogenesis of Crohn’s disease and ulcerative colitis. Additionally, models of intestinal inflammation may be used for the analysis of potentially new therapeutic agents. One key class of models consists of chemically induced inflammation models. Within this group, colitis induced by the haptenizing agent oxazolone is an important model that results in induction of acute or chronic inflammation of the large bowel. Here, we describe the induction and the analysis of this experimental colitis model.
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