Treatment of Allergic Rhinitis as a Strategy for Preventing Asthma

医学 哮喘 过敏 变应原免疫治疗 免疫疗法 重症监护医学 疾病 临床试验 随机对照试验 过敏性哮喘 免疫学 奥马佐单抗 免疫球蛋白E 过敏原 内科学 免疫系统
作者
Jaymin B. Morjaria,Massimo Caruso,Rosalia Emma,Cristina Russo,Riccardo Polosa
出处
期刊:Current Allergy and Asthma Reports [Springer Nature]
卷期号:18 (4) 被引量:30
标识
DOI:10.1007/s11882-018-0781-y
摘要

To evaluate the impact of allergic rhinitis (AR) on the development of asthma and to update readers on recent literature suggesting that early treatment of allergic subjects with immunotherapy may prevent asthma onset. AR is frequently associated with asthma, leading to the concept that these two conditions are different aspects of the same disease. There is increasing evidence that AR precedes the onset of asthmatic symptoms and current treatment strategies are beneficial in symptom control with no impact prevention. There is limited knowledge about the risk factors responsible for the progression of AR to asthma, though recent data supports the notion that it is possible to prevent asthma onset by allergen immunotherapy. Despite significant advances in specific immunotherapy (SIT) therapy strengthening its efficacy in AR and possible prevention of progression to asthma, the adoption of this therapeutic strategy is still restricted in comparison to therapies directed towards treatment of AR symptoms. Unlike corticosteroids and other symptomatic therapies, the benefit of SIT treatment in allergic individuals has been shown to prevent the development of allergic conditions. Hence, large well-conducted randomized clinical trials with long-term efficacy of SIT are required to confirm or refute the concept that SIT may abrogate the progression of AR to asthma in patients.
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