已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Long-Term Moderate Exercise Rescues Age-Related Decline in Hippocampal Neuronal Complexity and Memory

海马结构 海马体 神经科学 心理学 期限(时间) 老年学 衰老 医学 内科学 量子力学 物理
作者
Sheng‐Feng Tsai,N.-W. Ku,Tzu-Feng Wang,Yan-Hsiang Yang,Yao‐Hsiang Shih,Shih-Ying Wu,Chu-Wan Lee,Megan Yu,Ting-Ting Yang,Yu‐Min Kuo
出处
期刊:Gerontology [S. Karger AG]
卷期号:64 (6): 551-561 被引量:55
标识
DOI:10.1159/000488589
摘要

<b><i>Background:</i></b> Aging impairs hippocampal neuroplasticity and hippocampus-related learning and memory. In contrast, exercise training is known to improve hippocampal neuronal function. However, whether exercise is capable of restoring memory function in old animals is less clear. <b><i>Objective:</i></b> Here, we investigated the effects of exercise on the hippocampal neuroplasticity and memory functions during aging. <b><i>Methods:</i></b> Young (3 months), middle-aged (9–12 months), and old (18 months) mice underwent moderate-intensity treadmill running training for 6 weeks, and their hippocampus-related learning and memory, and the plasticity of their CA1 neurons was evaluated. <b><i>Results:</i></b> The memory performance (Morris water maze and novel object recognition tests), and dendritic complexity (branch and length) and spine density of their hippocampal CA1 neurons decreased as their age increased. The induction and maintenance of high-frequency stimulation-induced long-term potentiation in the CA1 area and the expressions of neuroplasticity-related proteins were not affected by age. Treadmill running increased CA1 neuron long-term potentiation and dendritic complexity in all three age groups, and it restored the learning and memory ability in middle-aged and old mice. Furthermore, treadmill running upregulated the hippocampal expressions of brain-derived neurotrophic factor and monocarboxylate transporter-4 in middle-aged mice, glutamine synthetase in old mice, and full-length TrkB in middle-aged and old mice. <b><i>Conclusion:</i></b> The hippocampus-related memory function declines from middle age, but long-term moderate-intensity running effectively increased hippocampal neuroplasticity and memory in mice of different ages, even when the memory impairment had progressed to an advanced stage. Thus, long-term, moderate intensity exercise training might be a way of delaying and treating aging-related memory decline.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
学术zha完成签到,获得积分10
1秒前
星辰大海应助chunyan_sysu采纳,获得10
2秒前
2秒前
学术zha发布了新的文献求助10
4秒前
勤劳钧发布了新的文献求助30
5秒前
catalpa关注了科研通微信公众号
5秒前
大模型应助夏昱采纳,获得10
7秒前
8秒前
9秒前
11秒前
Dr_Stars完成签到,获得积分10
12秒前
勤劳钧完成签到,获得积分10
13秒前
15秒前
好巧发布了新的文献求助30
15秒前
英姑应助samifranco采纳,获得10
15秒前
朴素剑心完成签到,获得积分10
18秒前
18秒前
Jasper应助蓝胖子采纳,获得10
19秒前
Helennewton完成签到,获得积分10
20秒前
kkk发布了新的文献求助10
21秒前
852发布了新的文献求助20
21秒前
bkagyin应助ppppppp_76采纳,获得10
21秒前
tangz7发布了新的文献求助20
22秒前
研友_n0Dmwn发布了新的文献求助10
26秒前
思源应助想学习想得不行采纳,获得10
27秒前
金金金发布了新的文献求助10
28秒前
整齐的达完成签到,获得积分10
30秒前
32秒前
33秒前
小小的梦想完成签到,获得积分10
33秒前
34秒前
卡皮巴拉发布了新的文献求助10
34秒前
路嘻嘻发布了新的文献求助10
37秒前
命运的X号发布了新的文献求助10
39秒前
40秒前
罗浩禹完成签到 ,获得积分10
40秒前
整齐的井完成签到 ,获得积分10
40秒前
希望天下0贩的0应助ning采纳,获得30
42秒前
wdnyrrc发布了新的文献求助10
43秒前
44秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
The diagnosis of sex before birth using cells from the amniotic fluid (a preliminary report) 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Semiconductor Process Reliability in Practice 720
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3229401
求助须知:如何正确求助?哪些是违规求助? 2877137
关于积分的说明 8197812
捐赠科研通 2544458
什么是DOI,文献DOI怎么找? 1374396
科研通“疑难数据库(出版商)”最低求助积分说明 646956
邀请新用户注册赠送积分活动 621749